Vitamin D dan COVID-19: Tinjauan Literatur
DOI:
https://doi.org/10.55175/cdk.v49i2.199Kata Kunci:
sistem imun, COVID-19, vitamin DAbstrak
Pendahuluan: Penyakit coronavirus (COVID-19) merupakan penyakit infeksi yang dideklarasikan WHO sebagai kasus gawat darurat kesehatan di dunia. Vitamin D diketahui memegang peranan dalam regulasi sistem imun baik pada penyakit infeksi maupun penyakit autoimun, sehingga vitamin D dapat bermanfaat pada tata laksana COVID-19. Metode: Tinjauan literatur COVID-19 dan kaitannya dengan vitamin D; sumber data dari Google Cendekia, PubMed, dan WHO. Hasil: Vitamin D berperan mengendalikan sistem sel imun seperti makrofag, limfosit, neutrofil, dan sel dendritik. Selain itu, mekanisme kerja innate dan adaptive immune system diperantarai oleh vitamin D, menghasilkan keseimbangan respons imun untuk meningkatkan respons anti-inflamasi. Simpulan: Vitamin D berkaitan dengan infeksi COVID-19 (dapat mengurangi risiko infeksi, mencegah perkembangan infeksi, dapat menurunkan tingkat keparahan, dan meringankan komplikasi badai sitokin; dengan demikian, dapat menurunkan morbiditas dan mortalitas akibat infeksi COVID-19.
Introduction: Coronavirus disease (COVID-19) is an infectious disease declared by WHO as a worldwide pandemic. Vitamin D supplementation is known to play a key role in regulating the immune system both in infectious and autoimmune diseases; it is believed to correlate with COVID-19. Method: A review of COVID-19 and their correlation with vitamin D, from the published data in Google Scholar, PubMed, and WHO. Result: Vitamin D play a role in the immune cell systems. It also regulates the innate immune system and adaptive immune system in response to increased anti-inflammatory response. Conclusion: Vitamin D can reduce the risk, prevent the development, and reduce the severity of infection and the effect of cytokines storm. Supplementation of vitamin D may reduce the morbidity and mortality of COVID-19.
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Referensi
Jain A, Chaurasia R, Sengar NS, Singh M, Mahor S, Narain S. Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers. Sci Rep. 2020;10(1):1–8. https://doi.org/10.1038/s41598-020-77093-z
WHO. WHO clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: Interim guidance [Internet]. 2020. Available from: https://www.who.int/internal-publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected.
Murdaca G, Pioggia G, Negrini S. Vitamin D and covid-19: An update on evidence and potential therapeutic implications. Clin Mol Allergy 2020;18(1):1–8. https://doi.org/10.1186/s12948-020-00139-0
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–33.
Xu Y, Baylink DJ, Chen CS, Reeves ME, Xiao J, Lacy C, et al. The importance of vitamin D metabolism as a potential prophylactic, immunoregulatory and neuroprotective treatment for COVID-19. J Transl Med. 2020;18(1):1–12.
Bleizgys A. Vitamin D and COVID-19: It is time to act. Int J Clin Pract. 2020;(September):1–9.
Kakodkar P, Kaka N, Baig M. A comprehensive literature review on the clinical presentation, and management of the pandemic coronavirus disease 2019 (COVID-19). Cureus. 2020;12:7560.
NHC. Notice of the National Health Commission of the People’s Republic of China on revising the English name of novel coronavirus pneumonia [Internet]. 2020. Available from: https://www.nhc.gov.cn/yzygj/s7653p/202002/3393aa53d984ccdb1053a52b6bef810.shtml.
Grant W, Lahore H, McDonnell S, Baggerly C, French C, Aliano J, et al. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020;12:4.
Bilezikian JP, Bikle D, Hewison M, Lazaretti-castro M, Formenti AM. Vitamin D and COVID-19. 2020;133–47.
Mitchell F. Vitamin-D and COVID-19: Do deficient risk a poorer outcome? Lancet Diabetes Endocrinol. 2020;8:570. https://doi.org/10.1016/S2213-8587(20)30183-2
Marazuela M, Giustina A, Puig-Domingo M. Endocrine and metabolic aspects of the COVID-19 pandemic. Rev Endocr Metab Disord. 2020;21(4):495-507. https://doi.org/10/1007/s11154-020-09569-2
Hastie CE, Pell JP, Sattar N. Vitamin D and COVID-19 infection and mortality in UK Biobank. Eur J Nutr. 2020;(0123456789):4–7. https://doi.org/10.1007/s00394-020-02372-4
Ross CA, Taylor CL, Yaktine AL. Dietary reference intakes for calcium and vitamin D. Inst Med Comm to Rev Diet Ref Intakes Vitam D Calcium. Washington (DC): National Academies Press (US); 2011.
23. Wacker M, Holick M. Vitamin D: Effects on skeletal and extraskeletal health and the need for supplementation. Nutrients 2013;5(1):111–48. https://doi.org/10.3390/nu501011
Bergman P. The link between vitamin D and COVID-19: Distinguishing facts from fiction. J Intern Med. 2020;289(1):131–3.
Holick M. Vitamin D deficiency. N Engl J Med. 2007;357:266–81.
Hewison M. Antibacterial effects of vitamin D. Nat Rev Endocrinol. 2011;7:337–45.
Kreutz M, Green F, Krause S, Szabo A, Ritz E, Reichel H. 1,25-dihydroxyvitamin D3 production and vitamin D3 receptor expression are developmentally regulated during differentiation of human monocytes into macrophages. Blood 1993;82:1300–7.
Hewison M, Freeman L, Hughes S, Evans K, Balnd R, Eliopoulos A, et al. Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells. J Immunol. 2003;170:5382–90. https://doi.org/10.4049/jimmunol.170.11.5382
Hewison M. Vitamin D and the intracrinology of innate immunity. Mol Cell Endocrinol. 2010;321:103–11. https://doi.org/10.1016/j.mce.2010.02.013
Holt P, Strickland D, Wikstrom M, Jahnsen F. Regulation of immunological homeostatis in the respiratory tract. Nat Rev Immunol. 2008;8:142–52. https://doi.org/10.1038/nri2236
Van Etten E, Mathieu C. Immunoregulation by 1,25-dihydroxyvitamin D3: Basic concepts. J Steroid Biochem Mol Biol. 2005;97:93–101. https://doi.org/10.1016/j.jsbmb.2005.06.002
Gregori S, Casorati M, Amuchastegui S, Smiroldo S, Davalli AM, Adorini L. Regulatory T cells induced by 1 alpha, 25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol. 2001;167:1945–53. https://doi.org/10.4049/jimmunol.167.4.1945
Daniel C, Sartory N, Zahn N, Radeke H, Stein J. Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile. J Pharmacol Exp Ther. 2008;324:23–33. https://doi.org/10.1124/jpet.107.127209
Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008;133:775–87. https://doi.orh/10.1016/j.cell.2008.05.009
Rudensky A. Regulatory T cells and Foxp3. Immunol Rev. 2011;241:260–8. https://doi.org/10.1111/j.1600-065X.2011.01018.x
Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science 2010;327:291–5. https://doi.org/10.1126/science.1183021
Hansdottir S, Monick M, Hinde S, Lovan N, Look D, Hunninghake G. Respiratory epithelial cells convert inactive vitamin D to its active form: Potential effects on host defense. J Immunol [Internet]. 2008;181:7090-9. https://doi.org/10.4049/jimmunol.181.10.7090
Rook G, Steele J, Fraher L, Barker S, Karmali R, O’Riordan J, et al. Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology 1986;57:159–63.
Liu P, Stenger S, Li H, Wenzel L, Tan B, Krutzik S, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006;311:1770–3. https://doi.org/10.1126/science.1123933
Wang T, Nestel F, Bourdeau V, Nagai Y, Wang Q, Liao J, et al. Cutting edge: 1,35-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol. 2004;173:2909–12. https://doi.org/10.4049/jimmunol.173.5.2909
Greiller C, Martineau A. Modulation of the immune response to repiratory viruses by vitamin D. Nutrients [Internet]. 2015;7:4240–3270. Available from: https://doi.org/10.3390/nu7064240
Yuk J, Shin D, Lee H, Yang C, Jin H, Kim K, et al. Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe [Internet]. 2009;6:231–43. Available from: https://doi.org/10.1016/j.chom.2009.08.004
Kim J, Yang Y, Jang S, Jang Y. Human beta-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of petentiating the induction of antigenspecific immunity. Virol J [Internet]. 2018;15:124. Available from: https://doi.org/10.1186/s12985-018-1035-2
Ahmed A, Siman-Tov G, Hall G, Bhalla N, Narayanan A. Human antimicrobial peptides as therapeutics for viral infections. Viruses [Internet]. 2019;11:704. Available from: https://doi.org/10.3390/v11080704
Barlow P, Svoboda P, Mackellar A, Nash A, York I, Pohl J, et al. Antiviral activity and increased host defense against influenza infection elicited by human cathelicidin LL-37. PLoS One [Internet]. 2011;6:25333. Available from: https://doi.org/10.1371/journal.pone.0025333
Mao J, Lin F, He I, Yu J, Tan P, Zhou Y. Autophagy and viral infection. Adv Exp Med Biol [Internet]. 2019;1209:55–78. Available from: https://doi.org/10.1007/978-981-15-0606-2_5
Lau F, Majumder R, Torabi R, Saeg F, Hoffman R, Cirillo J, et al. Vitamin D insufficiency is prevalent in severe COVID-19. medRxiv [Internet]. 2020; Available from: https://doi.org/101101/2020.04.24.20075838
Davolio A, Avateneo V, Manca A. 25-Hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients. 2020;12:1359.
Lanham-New S, Webb A, Cashman K, Buttris J, Fallowfield J, Msud T, et al. Vitamin D and SARS-CoV-2 virus/COVID-019 disease. BMJ Nutr Prev Heal. 2020;3:106–10.https://doi.org/10.1136/bmjnph-2020-000089
Daneshkhah A, Agrawal V, Eshein A. The possible role of vitamin D suppressing cytokine storm and associated mortality in COVID-19 patients. medRxiv [Internet]. 2020. Available from: https://www.medrxiv.org/content/10.1101/2020.04.08.20058578v4
Laird E, Kenny R. Vitamin D deficeincy in Ireland - implications for COVID-19. Results from The Irish Longitudinal Study on Ageing (TILDA) [Internet]. 2020 [cited 2021 Jan 20]. Available from: https://tilda.tcd.ie/publications/reports/pdf/Report_Covid19VitaminD.pdf
McCartney D, Byrne D. Optimisation of vitamin D status for enchanced immuno-protection against covid-19. Ir Med J. 2020;113:58.
Calder P, Carr A, Gombart A, Eggersdorfer M. Optimal nutritional status for well-functioning immune system in an important factor to protect against viral infections. Nutrients 2020;12:1181.
Ebadi M, Montano-Loza A. Perspective: Improving vitamin D status in the management of COVID-19. Eur J Clin Nutr. 2020;74:856–9.
Chen G, Wu D, Guo W. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020;130:2620–9.
Misra D, Agarwal V, Gasparyan A, Zimba O. Rheumatologists’ perspective on coronavirus disease 2019 (COVID-19) and potential therapeutic targets. Clin Rheumatol. 2020;39:2055–62.
Zabetakis I, Lordan R, Norton C, Tsoupras A. COVID-19: The inflammation link and the role of nutrition in potential mitigation. Nutrients 2020;12:1466.
Honardoost M, Ghavideldarestani M, Khamseh ME. Role of vitamin D in pathogenesis and severity of COVID-19 infection. Arch Physiol Biochem. 2020;0(0):1–7. https://doi.org/10.1080/13813455.2020.1792505
Wang C. A novel coronavirus outbreak of global health concern. Lancet 2020;395(10223):470–3.
Zhang J. Clinical characteristics of 140 patients infected by SARS-CoV-2 in Wuhan, China. Allergy 2020;75(7):1730–41.
Ohaegbulam KC, Swalih M, Patel P, Smith MA, Perrin R. Vitamin D supplementation in COVID-19 patients: A clinical case series. Am J Ther. 2020;27(5):485–90.
Lauer S, Grantz K, Bi Q. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: Estimation and application. Ann Intern Med. 2020;172:577–82.
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