Efek Suplementasi Vitamin D pada Kadar Hemoglobin Pasien Hemodialisis: Laporan Kasus Berbasis Bukti
Laporan Kasus Berbasis Bukti
DOI:
https://doi.org/10.55175/cdk.v53i03.2016Kata Kunci:
Anemia, hemodialisis, hemoglobin, vitamin DAbstrak
Latar belakang: Anemia merupakan salah satu komplikasi umum penyakit ginjal kronik (PGK) stadium akhir, terutama pasien yang menjalani hemodialisis. Vitamin D, mikronutrien dengan reseptor pada banyak sel, juga memiliki peran meningkatkan eritropoiesis dengan meningkatkan proliferasi sel progenitor eritrosit, serta menurunkan ekspresi sitokin proinflamasi dan hepsidin, sehingga meningkatkan bioavailabilitas besi untuk sintesis Hb. Studi ini bertujuan menelaah pengaruh suplementasi vitamin D terhadap kadar Hb pasien hemodialysis kronik. Metode: Pencarian literatur dilakukan pada 4 basis data: PubMed, ProQuest, Cochrane, Scopus. Kriteria inklusi berupa studi dengan subjek dewasa yang menjalani hemodialisis rutin dan mengalami anemia dengan status vitamin D apapun yang dipublikasi dalam 5 tahun terakhir, merupakan systematic reviews dan meta-analyses (SR-MA) dari randomized controlled trial (RCT) atau RCT. Pengkajian kritis dilakukan dengan perangkat yang mencakup komponen VIA dari OCEBM. Hasil: Dua artikel RCT dan satu SR-MA dikaji secara kritis. Suplementasi vitamin D dapat meningkatkan kadar Hb pada pasien hemodialisis kronik, efek signifikan dicapai pada durasi suplementasi lebih panjang. Simpulan: Suplementasi vitamin D pada pasien hemodialisis kronik menunjukkan hasil menjanjikan terhadap perbaikan kadar Hb. Diperlukan penelitian lebih lanjut mengenai jenis, dosis, dan durasi suplementasi vitamin D yang optimal.
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