Fibroid Uterus dan Infertilitas

Penulis

  • Arif Tantri Hartoyo Departemen-KSM Obstetri Ginekologi, Fakultas Kedokteran Kesehatan Masyarakat dan Keperawatan, Universitas Gadjah Mada-RSUP Dr. Sardjito Yogyakarta, Indonesia
  • Nuring Pangastuti Departemen-KSM Obstetri Ginekologi, Fakultas Kedokteran Kesehatan Masyarakat dan Keperawatan, Universitas Gadjah Mada-RSUP Dr. Sardjito Yogyakarta, Indonesia

DOI:

https://doi.org/10.55175/cdk.v49i3.208

Kata Kunci:

Fibroid, infertilitas, leiomioma, mioma

Abstrak

Fibroid uterus (mioma atau leiomioma) adalah tumor monoklonal jinak sel otot polos rahim manusia. Fibroid merupakan tumor uterus yang paling umum dijumpai pada kelompok usia reproduksi. Keberadaannya dapat tanpa gejala, bergejala ringan hingga berat. Faktor risiko fibroid termasuk usia, ras, faktor hormon endogen ataupun eksogen, obesitas, infeksi rahim, serta gaya hidup (diet, konsumsi kafein dan alkohol, aktivitas fisik, stres, merokok). Klasifikasi fibroid mengikuti panduan FIGO untuk leiomioma. Diagnosis berdasarkan tanda dan gejala, pemeriksaan fisik dan penunjang. Fibroid dapat merupakan faktor terjadinya infertilitas antara lain melalui jalur perubahan fisik dan kontraksi uterus, perubahan faktor implantasi, ataupun zona junctional endometrium.

Uterine fibroids (myoma or leiomyoma) are benign monoclonal tumors of smooth muscle cells in the human uterus. Fibroids are the most common uterine tumors in reproductive age group. It can be without symptoms or with mild to severe symptoms. Risk factors include age, race, endogenous and exogenous hormone factors, obesity, uterine infections, and lifestyle (diet, consumption of caffeine and alcohol, physical activity, stress, smoking). Its classification follows the FIGO sub-classification system for leiomyomas. Diagnosis is from clinical findings and supporting additional examination. Fibroids can affect fertility through physical changes and uterine contractions, changes in implantation factors and the junctional zone of the endometrium.

Unduhan

Data unduhan belum tersedia.

Referensi

Pavone D, Clemenza S, Sorbi F, Fambrini M, Petraglia F. Epidemiology and risk factors of uterine fibroids. Best Prac Res Clin Obstet Gynaecol. 2018;46:3-11.

Sparic R, Mirkovic L, Malvasi A, Tinelli A. Epidemiology of uterine myomas: A review. Int J Fertil Steril. 2016;9(4):424-35. doi:10.22074/ijfs.2015.4599.

Wise LA, Palmer JR, Stewart EA, Rosenberg L. Age-specific incidence rates for self-reported uterine leiomyomata in the Black Women’s Health Study. Obstet Gynecol. 2005;105:563e8.

Wechter ME, Stewart EA, Myers ER, Kho RM, Wu JM. Leiomyoma-related hospitalization and surgery: Prevalence and predicted growth based on population trends. Am J Obstet Gynecol. 2011;205(5):492.1-5.

Mehine M, Kaasinen E, Mäkinen N, Katainen R, Kämpjärvi K, Pitkänen E, et al. Characterization of uterine leiomyomas by whole-genome sequencing. N Engl J Med. 2013;369(1):43-53. doi: 10.1056/NEJMoa1302736. Epub 2013 Jun 5. PMID: 23738515.

Wise LA, Laughlin-Tommaso SK. Uterine leiomyomata. In: Goldman MB, Troisi R, Rexrode KM, editors. Women and health. San Diego: Academic Press; 2013 .pp.285–306.

Tsigkou A, Reis FM, Lee MH, Jiang B, Tosti C, Centini G, et al. Increased progesterone receptor expression in uterine leiomyoma: correlation with age, number of leiomyomas, and clinical symptoms. Fertil Steril. 2015;104(1):170-5.e1.

Wise LA, Laughlin-Tommaso SK. Epidemiology of uterine fibroids: From menarcheto menopause. Clin Obstet Gynecol. 2016;59(1):2-24.

Protic O, Toti P, Islam MS, Occhini R, Giannubilo SR, Catherino WH, et al. Possible involvement of inflammatory/reparative processes in the development of uterine fibroids. Cell Tissue Res. 2016;364(2):415-27.

Ciavattini A, Carpini GD, Moriconi L, Clemente N, Orici F, Boschi AC, et al. The association between ultrasound-estimated visceral fat deposition and uterine fibroids: an observational study. Gynecol Endocrinol. 2017;33(8):634-7.

He Y, Zeng Q, Dong S, Qin L, Li G, Wang P. Associations between uterine fibroids and lifestyles including diet, physical activity and stress: A case-control study in China. Asia Pac J Clin Nutr. 2013;22(1):109-17. doi: 10.6133/apjcn.2013.22.1.07. PMID: 23353618.

Wise LA, Radin RG, Kumanyika SK, Ruiz-Navaez EA, Palmer JR, Rosenberg L. Prospective study of dietary fat and risk of uterine leiomyomata. Am J Clin Nutr.2014;99(5):1105-16.

Woźniak A, Woźniak S. Ultrasonography of uterine leiomyomas. Prz Menopauzalny. 2017;16(4):113-7. doi:10.5114/pm.2017.72754.

Fleischer AC. Color Doppler sonography of uterine disorders. Ultrasound Q. 2003;19(4):179-89.

Purohit P, Vigneswaran K. Fibroids and infertility. Curr Obstet Gynecol Rep. 2016;5:81-8. doi:10.1007/s13669-016-0162-2.

Ben-Nagi J, Miell J, Mavrelos D, Naftalin J, Lee C, Jurkovic D. Endometrial implantation factors in women with submucous uterine fibroids. Reprod Biomed Online. 2010;21(5):610-5. doi: 10.1016/j.rbmo.2010.06.039.

Richlin SS, Ramachandran S, Shanti A, Murphy AA, Parthasarathy S. Glycodelin levels in uterine flushings and in plasma of patients with leiomyomas and polyps: Implications for implantation. Hum Reprod. 2002;17:2742–7.

Brosens I, Derwig I, Brosens J, Fusi L, Benagiano G, Pijnenborg R. The enigmatic uterine junctional zone: The missing link between reproductive disorders and major obstetrical disorders? Hum Reprod. 2010;25:569-74.

Ciavattini A, Di Giuseppe J, Stortoni P, Montik N, Giannubilo SR, Litta P, et al. Uterine fibroids: Pathogenesis and interactions with endometrium and endomyometrial junction. Obstet Gynecol Int. 2013;2013:173-84.

Kitaya K, Yasuo T. Leukocyte density and composition in human cycling endometrium with uterine fibroids. Hum Immunol. 2010;71:158-63.

Tocci A, Greco E, Ubaldi FM. Adenomyosis and ‘endometrial-subendometrial myometrium unit disruption disease’ are two different entities. Reprod Biomed Online. 2008;17:281-91.

Malvasi A, Cavallotti C, Morroni M, Lorenzi T, Dell’Edera D, Nicolardi G, et al. Uterine fibroid pseudocapsule studied by transmission electron microscopy. Eur J Obstet Gynecol Reprod Biol. 2012;162(2):187-91.

Diterbitkan

2022-03-01

Cara Mengutip

Hartoyo, A. T., & Pangastuti, N. (2022). Fibroid Uterus dan Infertilitas. Cermin Dunia Kedokteran, 49(3), 143–146. https://doi.org/10.55175/cdk.v49i3.208

Terbitan

Bagian

Articles