Peranan Suplemen dalam Tata Laksana Infertilitas
DOI:
https://doi.org/10.55175/cdk.v49i4.217Kata Kunci:
Antioksidan, infertilitas, mikronutrien, stres oksidatifAbstrak
Infertilitas adalah tidak terjadinya kehamilan setelah 12 bulan menjalani hubungan seksual rutin tanpa proteksi atau kontrasepsi. Infertilitas memiliki dampak buruk baik secara pribadi maupun sosial karena meningkatkan angka kekerasan dalam rumah tangga, perceraian, stres emosional, dan rendahnya kepercayaan diri. Infertilitas dapat disebabkan oleh faktor pria ataupun wanita. Suplementasi antioksidan dan mikronutrien banyak diteliti untuk meningkatkan fertilitas baik secara langsung maupun tidak langsung dengan mengurangi stres oksidatif dan meningkatkan fungsi reproduksi.
Infertility defined as the absence of pregnancy after 12 months of routine sexual intercourse without protection or contraception. Infertility has devastating effects both personally and socially by increasing incidence of domestic violence, divorce, emotional stress, and low self-esteem. Infertility can be caused by either male or female factors. Antioxidant and micronutrient supplementation has been widely studied to increase fertility directly and indirectly by reducing oxidative stress and improving reproductive function
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Referensi
Infertility [Internet]. Who.int. 2021 [cited 5 March 2021]. Available from: https://www.who.int/news-room/fact-sheets/detail/infertility
Infertility [Internet]. nhs.uk. 2021 [cited 5 March 2021]. Available from: https://www.nhs.uk/conditions/infertility/
Infertility | Reproductive Health | CDC [Internet]. Cdc.gov. 2021 [cited 5 March 2021]. Available from: https://www.cdc.gov/reproductivehealth/infertility/index.htm
Arsyad SS, Nurhayati S, Determinan Fertilitas di Indonesia. J Kependudukan Indon. 2016;11(1):1-14.
Lindsay TJ, Vitrikas KR. Evaluation and treatment of infertility. Am Fam Physician. 2015;91(5):308-14.
Zini A, Libman J. Oxidative Stress and Male Infertility. Systems Biology of Free Radicals and Antioxidants. 2014; 2815-2833.
Mahajan SK. Effect of oral zinc therapy on gonadal function in hemodialysis patients. Annals of Internal Medicine. 1982;97(3):357.
Dawson EB, Harris WA, Teter MC, Powell LC. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril. 1992;58(5):1034–9.
Lenzi A, Culasso F, Gandini L, Lombardo F, Dondero F. Andrology: Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility. Human Reproduction. 1993;8(10):1657–62.
Suleiman SA, Ali ME, ZakiZM, el-MalikEM,Nasr MA. Lipid peroxidation and human sperm motility: protective role of vitamin E. J Androl. 1996;17(5):530-7.
Scott R, Macpherson A, Yates RWS, Hussain B, Dixon J. The effect of oral selenium supplementation on human sperm motility. BJU Internat. 1998;82(1):76–80.
Wong WY, Merkus HMWM, Thomas CMG, Menkveld R, Zielhuis GA, Steegers-Theunissen RPM. Effects of folic acid and zinc sulfate on male factor subfertility: A double-blind, randomized, placebo-controlled trial. Fertil Steril. 2002;77(3):491–8.
Lenzi A, Lombardo F, Sgrò P, Salacone P, Caponecchia L, Dondero F, et al. Use of carnitine therapy in selected cases of male factor infertility: A double-blind crossover trial. Fertil Steril. 2003;79(2):292–300.
Comhaire FH, Garem YE, Mahmoud A, Eertmans F, Schoonjans F. Combined conventional/antioxidant “astaxanthin” treatment for male infertility: A double blind, Randomized Trial. Asian J Andrology. 2005;7(3):257–62.
Ciftci H, Verit A, Savas M, Yeni E, Erel O. Effects of N-acetylcysteine on semen parameters and oxidative/antioxidant status. Urology. 2009;74(1):73–6.
Kader A, Choi A, Orief Y, Agarwal A. Factors affecting the outcome of human blastocyst vitrification. Reproductive Biol Endocrinol. 2009;7(1):99.
Surasandi D, Anantasika AAN. The role of superoxide dismutase on pregnancy rates of women undergoing intrauterine insemination. Bali Med J. 2017;6(1):114.
Ursini F, Heim S, Kiess M, Maiorino M, Roveri A, Wissing J, et al. Dual function of the selenoprotein phgpx during sperm maturation. Science. 1999;285(5432):1393–6.
Mukherjee A, Malik H, Saha AP, Dubey A, Singhal DK, Boateng S, et al. Resveratrol treatment during goat oocytes maturation enhances developmental competence of parthenogenetic and hand-made cloned blastocysts by modulating intracellular glutathione level and embryonic gene expression. J Assisted Reproduction Genetics. 2014;31(2):229–39.
Lim J, Lawson GW, Nakamura BN, Ortiz L, Hur JA, Kavanagh TJ, et al. Glutathione-deficient mice have increased sensitivity to transplacental benzo[a]pyrene-induced premature ovarian failure and ovarian tumorigenesis. Cancer Res. 2013;73(2):908–17.
Adeoye O, Olawumi J, Opeyemi A, Christiania O. Review on the role of glutathione on oxidative stress and infertility. JBRA Assisted Reproduction. 2017.
Espino J, Macedo M, Lozano G, Ortiz Á, Rodríguez C, Rodríguez A et al. Impact of Melatonin Supplementation in Women with Unexplained Infertility Undergoing Fertility Treatment. Antioxidants. 2019;8(9):338.
Hu K, Ye X, Wang S, Zhang D. Melatonin Application in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis of Randomized Trials. Front Endocrinol. 2020;11.
Sun T, Li H, Li X, Yu K, Deng S, Tian L. Protective effects of melatonin on male fertility preservation and reproductive system. Cryobiology. 2020;95:1-8.
Alahmar A, Calogero A, Sengupta P, Dutta S. Coenzyme Q10 Improves Sperm Parameters, Oxidative Stress Markers and Sperm DNA Fragmentation in Infertile Patients with Idiopathic Oligoasthenozoospermia. World J Men’s Health. 2021;39(2):346.
Zhang M, ShiYang X, Zhang Y, Miao Y, Chen Y, Cui Z et al. Coenzyme Q10 ameliorates the quality of postovulatory aged oocytes by suppressing DNA damage and apoptosis. Free Radical Biol Med. 2019;143:84-94.
Florou P, Anagnostis P, Theocharis P, Chourdakis M, Goulis D. Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials. J Assisted Reproduction and Genetics.2020;37(10):2377-2387.
Buhling K, Grajecki D. The effect of micronutrient supplements on female fertility. Curr Opin Obstetr Gynecol. 2013;25(3):173-180.
Buhling K, Laakmann E. The effect of micronutrient supplements on male fertility. Curr Opin Obstetr Gynecol. 2014;26(3):199-209.
Gaskins A, Afeiche M, Wright D, Toth T, Williams P, Gillman M et al. Dietary Folate and Reproductive Success Among Women Undergoing Assisted Reproduction. Obstetr Gynecol. 2015;124(4):801-809.
Ciccone IM, Costa EM, Pariz JR, et al. Serum vitamin D content is associated with semen parameters and serum testosterone levels in men. Asian J Androl. 2021;23(1):52-58.
Nazari L, Salehpour S, Hosseini S, et al. Effect of antioxidant supplementation containing L-Carnitine on semen parameters: a prospective interventional study. JBRA Assist Reprod. 2021;25(1):76-80.
Grieger J, Grzeskowiak L, Wilson R, Bianco-Miotto T, Leemaqz S, Jankovic-Karasoulos T et al. Maternal Selenium, Copper and Zinc Concentrations in Early Pregnancy, and the Association with Fertility. Nutrients. 2019;11(7):1609.
Martínez-Soto J, Domingo J, Cordobilla B, Nicolás M, Fernández L, Albero P et al. Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation. Systems Biology in Reproductive Medicine. 2016;62(6):387-395.
Mendoza N, Diaz-Ropero M, Aragon M, Maldonado V, Llaneza P, Lorente J et al. Comparison of the effect of two combinations of myo-inositol and D-chiro-inositol in women with polycystic ovary syndrome undergoing ICSI: a randomized controlled trial. Gynecol Endocrinol. 2019;35(8):695-700.
Mendoza N, Galan M, Molina C, Mendoza-Tesarik R, Conde C, Mazheika M et al. High dose of d-chiro-inositol improves oocyte quality in women with polycystic ovary syndrome undergoing ICSI: a randomized controlled trial. Gynecol Endocrinol. 2019;36(5):398-401.
Ghafarizadeh A, Malmir M, Naderi Noreini S, Faraji T. Antioxidant effects of N-acetylcysteine on the male reproductive system: A systematic review. Andrologia. 2020;53(1).
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