Red cell Distribution Width sebagai Prediktor Penyakit Kardiovaskuler
DOI:
https://doi.org/10.55175/cdk.v46i11.410Kata Kunci:
Biomarker, red cell distribution width, penyakit kardiovaskulerAbstrak
Baru-baru ini, sejumlah besar penelitian telah menemukan hubungan independen di luar faktor risiko tradisional antara peningkatan RDW (anisositosis) dan penyakit kardiovaskuler. Red cell distribution width (RDW) adalah ukuran variasi ukuran dan indeks heterogenitas eritrosit. RDW juga dikaitkan dengan mortalitas penyakit kardiovaskuler dan mortalitas umum pada populasi yang berbeda. Masih harus diteliti lebih lanjut, apakah RDW hanya suatu biomarker atau juga mediator patogen untuk penyakit kardiovaskuler tertentu.
Recently, a large number of studies have found an independent association beyond traditional risk factors between increased RDW (anisocytosis) and cardiovascular diseases (CVDs). Red cell distribution width (RDW) is a measure of size variation and heterogeneity index of erythrocytes. RDW is also associated with cardiovascular disease mortality and general mortality in different populations. It remains to be determined whether RDW is only a biomarker or also a pathogenic mediator for certain CVDs.
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Towsend N, Wilson L, Bhatnagar P, Wickramasinghe K, Rayner M, Nichols M. Cardiovascular disease in Europe 2016: An epidemiological update. Eur Heart J 2016; 37: 3182-83
Clarke K, Sagunarthy R, Kansal S. RDW is an additional marker in inflammatory bowel disease. Digestive Dis Sci 2008;53:2521-3
Tseliou E, Terrovitis JV, Kaldara EE, Ntalianis AS, Repasos E, Katsaros L, et al. Red blood cell distribution width is a significant prognostic marker in advanced heart failure, independent of hemoglobin levels. Hellenic J Cardiol. 2014;55:457-61
Anderson JL, Ronnow BS, Horne BD, Carlquist JF, May HT, Bair TL, et al. Usefulness of a complete blood count-derived risk score to predict incident mortality in patients with suspected cardiovascular disease. Am J Cardiol. 2007;99:169-74
Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: a simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci. 2015;52:86
Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relationship between red blood cell distribution width and kidney function tests in a large cohort of unselected outpatients. Scand J Clin Lab Invest. 2008;68:745-8
Montagnana M, Cervellin G, Meschi T, Lippi G. The role of red blood cell distribution width in cardiovascular and thrombotic disorders. Clin Chem Lab Med. 2011;50:635-41
Tanindi A, Topal FE, Topal F, Celik B. Red cell distribution width in patients with prehypertension and hypertension. Blood Press. 2012;21:177-81
Hampole CV, Mehrotra AK, Thenappan T, Gomberg-Maitland M, Shah SJ. Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension. Am J Cardiol. 2009;104:868-72
Adamsson Eryd S, Borné Y, Melander O, Persson M, Smith JG, Hedblad B, et al. Red blood cell distribution width is associated with incidence of atrial fibrillation. J Intern Med. 2014;275:84-92
Fukuta H, Ohte N, Mukai S, Saeki T, Asada K, Wakami K, et al. Elevated plasma levels of B-type Natriuretic Peptide but not C-reactive protein are associated with higher red cell distribution width in patients with coronary artery disease. Int Heart J. 2009; 50: 301-12
Adams KF Jr, Mehra MR, Oren RM, O'Connor CM, Chiong JR, Ghali JK, et al. Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure. Am Heart J. 2010;160:1142-8.
Ozsu S, Abul Y, Gulsoy A, Bulbul Y, Yaman S, Ozlu T. Red cell distribution width in patients with obstructive sleep apnea syndrome. Lung. 2012;190:319-26
Carertero OA, Oparil S. Essential hypertension. Part I: Definition and etiology. Circulation 2000; 101: 329-35
Buyukkaya A, Erayman A, Karakas E, Bugra Nacar A, Kurt M, Buyukkaya S, et al. Relation of red cell distribution width with dipper and non-dipper hypertension. Medicinski Glasnik 2016;13:75-81
Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M; for the Cholesterol and Recurrent Events (CARE) Trial Investigators. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation. 2008; 117: 163-8.
Kurtoğlu E, Aktürk E, Korkmaz H, Sincer I, Yılmaz M, Erdem K, et al. Elevated red blood cell distribution width in healthy smokers. Turk Kardiyol Dern Ars. 2013;41:199-206.
Felker GM, Allen LA, Pocock SJ, Shaw LK, McMurray JJ, Pfeffer MA, et al. Red cell distribution width as a novel prognostic marker in heart failure: data from CHARM Program and the Duke Databank. J Am Coll Cardiol. 2007;50:40-7.
Liu T, Shao Q, Miao S, Liu E, Xu G, Yuan R, et al. Red cell distribution width as a novel, inexpensive marker for paroxysmal atrial fibrillation. Int J Cardiol. 2014;171:52-3.
Rhodes CJ, Wharton J, Howard LS, Gibbs JS, Wilkins MR. Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension. Heart. 2011;97:1054-60.
Zorlu A, Bektasoglu G, Guven FM, Dogan OT, Gucuk E, Ege MR, et al. Usefulness of admission red cell distribution width as a predictor of early mortality in patients with acute pulmonary embolism. Am J Cardiol. 2012;109:128-34.
Sen HS, Abakay O, Tanrikulu AC, Sezgi C, Taylan M, Abakay A, et al. Is a complete blood cell count useful in determining the prognosis of pulmonary embolism? Wien Klin Wochenschr. 2014;126:347-54.
Xi Q, Wang Y, Liu Z, Zhao Z, Luo Q. Red cell distribution width predicts chronic thromboembolic pulmonary hypertension in patients with acute pulmonary embolism in a long-term follow-up. Clin Chem Lab Med. 2014;52(9):191-5.
Abul Y, Ozsu S, Korkmaz A, Bulbul Y, Orem A, Ozlu T. Red cell distribution width: A new predictor for chronic thromboembolic pulmonary hypertension after pulmonary embolism. Chron Respir Dis 2014;11:73-81
Cay N, Unal O, Kartal MG, Ozdemir M, Tola M. Increased level of red blood cell distribution width is associated with deep venous thrombosis. Blood Coagul Fibrinolysis 2013;24:727-31
Patel KV, Mohanty JG, Kanapuru B, Hesdorffer C, Ershler WB, Rifkind JM. Association of the red cell distribution width with red blood cell deformity. Springer New York, USA; 2013.
Güneş H, Ekmekci A, Uslu AU, Eren M, Yilmaz MB. Plasma osmolality predicts mortality in patients with heart failure. J Am Coll Cardiol. 2013;18:18
Forhecz Z, Gombos T, Borgulya G, Pozsonyi Z, Prohászka Z, Jánoskuti L. Red cell distribution width in heart failure: Prediction of clinical event and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J. 2009;158:659-66
Lee WH, Hsu PC, Chu CY, Lee HH, Lee MK, Lee CS, et al. Anemia is an independent predictor outcomes in patient with atrial fibrillation. Internat J Med Sci. 2015;12:618-24
Pierce CN, Larson DF. Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device. Perfusion 2005;20:83-90.
Zyga S, Kolovos P. Cardiovascular disease and chronic inflammation in end stage kidney disease. Internat J Caring Sci. 2013;6:291. Towsend N, Wilson L, Bhatnagar P, Wickramasinghe K, Rayner M, Nichols M. Cardiovascular disease in Europe 2016: An epidemiological update. Eur Heart J 2016; 37: 3182-83
Melgarlesmes P, Garcia-Polite F, Del Rey Puech P, Rosas E, Dreyfuss JL, Montell E, et al. Treatment with chondroitin sulfate to modulate inflammation and atherogenesis in obesity. Atherosclerosis 2016;245:82-7.
Carnevali S, Petruzzelli S, Longoni B, Vanacore R, Barale R, Cipollini M, et al. Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblast. Am J Physiol Lung Cell Mol Physiol. 2003;284:1955-63.
Skjelbakken T, Lappegård J, Ellingsen TS, Barrett-Connor E, Brox J, Løchen ML, et al. Red cell distribution width is associated with incident myocardial infarction in a general population: The Tromsø study. J Am Heart Assoc. 2014;3:845–47
Karthikeyan VJ, Lip GYH. Oxidative stress and hypertension. Internati J Clin Pract. 2014;60:1525–27
Baskurt OK et al. Oxidant stress and deformability in the red blood cell under the influence of sulfur dioxide inhalation 2004
Engstrom B, Hedblad B, Tydén P, Lindgärde F. Inflammation-sensitive plasma proteins are associated with increased incidence of heart failure: A population-based cohort study. Atherosclerosis 2009;202:617–22
Engström G, Smith JG, Persson M, Nilsson PM, Melander O, Hedblad B. Red cel distribution width, haemoglobin A1c and incidence of diabetes mellitus. J Intern Med. 2014;276:174-83.
D’Alessandro A, Blasi B, D’Amici GM, Marrocco C, Zolla L. Red blood cell subpopulations in freshly drawn blood: Application of proteomics and metabolomics to a decades-long biological issue. Blood Transfusion 2013;11:75-87.
Zöller B, Melander O, Svensson P, Engström G. Red cell distribution width and risk for venous thromboembolism: A population-based cohort study. Thrombosis Res. 2014;133:334-9
Yoon HE, Kim SJ, Hwang HS, Chung S, Yang CW, Shin SJ. Progressive rise in red blood cell distribution width predict mortality and cardiovascular event in end-stage renal disease patients. PLoS One 2015;10(5):e0126272.
Li ZZ, Chen L, Yuan H, Zhou T, Kuang ZM. Relationship between red blood cell distribution width and early-stage renal function damage in patients with essential hypertension. J Hypertens. 2014;32:2450–6
Zhang M, hang Y, Li C, He L. Association between red blood cell distribution and renal function in patients with untreated type 2 diabetes mellitus. Renal Failure 2015;37:659–63
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