Tinjauan atas Norepinephrine – First Line Vasopressor for Septic Shock

Penulis

  • Martinova Sari Panggabean Medical Department PT Kalbe Farma Tbk., Medan, Indonesia

DOI:

https://doi.org/10.55175/cdk.v46i11.413

Kata Kunci:

Norepinephrine, syok sepsis, vasopressor

Abstrak

Syok sepsis termasuk kedaruratan medis yang memerlukan resusitasi adekuat. Salah satu hal penting saat resusitasi awal adalah penggunaan vasoaktif untuk mencapai target MAP 65 mmHg sesegera mungkin. Terapi agen vasoaktif harus dimulai untuk mempertahankan tekanan arteri dan perfusi organ yang adekuat. Norepinephrine merupakan vasopressor pilihan pertama pada pasien syok sepsis.

Septic shock is a life-threatening emergency that require adequate resuscitation. The use of vasoactive is important to achieve the 65 mmHg MAP target as soon as possible. Vasoactive agents should be initiated to restore adequate arterial pressure and organ perfusion. Norepinephrine is the first line vasopressor in patients with septic shock.

Unduhan

Data unduhan belum tersedia.

Referensi

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus definitions-for sepsis and septic shock (sepsis-3). J Am Med Assoc. 2016;315(8):801-10.

McLymont N, Glover GW. Scoring systems for the characterization of sepsis and associated outcomes. Ann Transl Med. 2016;4(24):527. doi: 10.21037/atm.2016.12.53

Nick BA, Gaillard J. In: Tintinalli’s emergency medicine: A comprehensive study guide. 8th Edition. Section 3, chapter 12: Approach to shock [Internet]. 2016:63-8. [cited 2019 May]. Available from: https://accessmedicine.mhmedical.com/content.aspx?bookid=1658&sectionid=109384946

Gaieski DF, Mikkelsen ME. Definition, classification, etiology, and pathophysiology of shock in adults. [cited 2019 May]. Available from: https://www.uptodate.com/contents/definition-classification-etiology-and-pathophysiology-of-shock-in-adults

Bonanno FG. Clinical pathology of the shock syndromes. J Emerg Trauma Shock [Internet] 2011. [cited 2019 May];4:233-43. Available from: http://www.onlinejets.org/text.asp?2011/4/2/233/82211)

Thomovsky E, Johnson P. Shock pathophysiology. Compendium (Yardley, PA) [Internet]. 2013;35:1-9. [cited 2019 May]. Available from: https://vetfolio-vetstreet.s3.amazonaws.com/f8/a1e900bd7511e28e71005056ad4736/file/PV2013_Thomovsky_CE.pdf

Worthley LIG. Shock: A review of pathophysiology and management: Part I. Critical care and resuscitation [Internet];2000:2, 55-65. [cited 2019 May]. Available from: https://www.cicm.org.au/CICM_Media/CICMSite/CICM-Website/Resources/Publications/CCR%20Journal/Previous%20Editions/March%202000/11_2000_Mar_Shock-A-Review-Part-1.pdf

Richards J, Wilcox S. Diagnosis and management of shock in the emergency department. Emergency medicine practice [Internet]. 2014 [cited 2019 May]. Available from: www.cmua.nl/Cmua/Inwerken_files/0314%20Shock.pdf

Avegno J. Shock [Internet]. 2008 [cited 2019 May]. Available from: https://www.saem.org/cdem/education/online-education/m3-curriculum/group-stabilizationof-the-acutely-ill-patient/approach-to-shock

Marik PE, Taeb AM. SIRS, qSOFA and new sepsis definition. J Thorac Dis. 2017;9(4):943-5.

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315:801-10.

Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. Surviving sepsis campaign: International guidelines for management of sepsis and septic shock: 2016. Intensive Care Med. 2017;43(3):304-77.

Dellinger RP, Schorr CA, Levy MM. A users’ guide to the 2016 surviving sepsis guidelines. Society of Critical Care Medicine and Wolter Kluwer Health. 2017; 43:299–303

Levy MM, Evans LE, Rhodes A. The surviving sepsis campaign bundle: 2018 Update. 2018. The Society of Critical Care Medicine and the European Society of Intensive Medicine [Internet]. [cited 2019 June]. Available from: http://www.survivingsepsis.org/SiteCollectionDocuments/Surviving-Sepsis-Campaign-Hour-1-Bundle-2018.pdf

Pangalila F, Mansjoer A. Penatalaksanaan sepsis dan syok septik. Optimalisasi FASTHUGBUD. Perhimpunan Dokter Intensive Care Indonesia. 2017.

LEVOPHED® [Internet]. 2007 [cited 2019 July]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/007513Orig1s024lbl. pdf.

US National Library of Medicine. Norepinephrine in toxicology data network [Internet]. 2010. Available from: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+@rel+51-41-2)

DRUGBANK. Norepinephrine [Internet]. Avaialable from: https://www.drugbank.ca/drugs/DB00368

Product Knowledge Efrala. PT. Kalbe Farma. 2018

Diterbitkan

2019-11-01

Cara Mengutip

Panggabean, M. S. (2019). Tinjauan atas Norepinephrine – First Line Vasopressor for Septic Shock. Cermin Dunia Kedokteran, 46(11), 708–711. https://doi.org/10.55175/cdk.v46i11.413

Terbitan

Bagian

Articles