Rifampisin Ofloksasin Minosiklin (ROM) sebagai Terapi Alternatif Morbus Hansen
DOI:
https://doi.org/10.55175/cdk.v46i10.417Kata Kunci:
Kusta, morbus hansen, ROM (rifampicin-ofloksasin-minosiklin)Abstrak
Morbus Hansen merupakan penyakit infeksi yang masih terus muncul. Multi-drug therapy (MDT) dari WHO banyak bermanfaat, namun masih belum bisa mengeradikasi penyakit ini. Kombinasi Rifampisin-Ofloksasin-Minosiklin memiliki efek anti-kusta yang menjanjikan dan mungkin dapat digunakan sebagai terapi alternatif Morbus Hansen.
Morbus Hansen is an infectious disease that is still a problem. MDT from WHO have been very useful, but still can’t eradicate leprosy. A combination therapy of Rifampicin-Ofloxacin-Minocyclin appeared to be promising and can be used as an alternative therapy.
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Referensi
World Health Organization. WHO to publish first official guidelines on leprosy diagnosis, treatment and prevention [Internet]. 2018. Available from: http://www.who.int/neglected_diseases/news/WHO-to-publish-first-guidelines-on-leprosy-diagnosis/en/
Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell JE, Wolff K. Fitzpatrick’s dermatology in general medicine. 8th. Mc. Graw Hill; 2012.
Setia MS, Shinde SS, Jerajani HR, Boivin JF. Is there a role for rifampicin, ofloxacin, and minocycline (ROM) therapy in the treatment of leprosy systematic review and meta-analysis. Trop Med Int Health 2011;16(12):1541-51.
Moestopo O, Gunawan H, Dahlan A. Comparison of effectiveness between rifampicin ofloxacin- minocycline regimen and multidrug therapy-World Health Organization in multibacillary leprosy patient. Althea Med J. 2016;3(4):661-5.
Pedoman Nasional Program Pengendalian Penyakit Kusta. Kementrian Kesehatan Republik Indonesia. Direktorat Jenderal Pengendalian Penyakit dan Penyehatan Lingkungan. 2012
NIH. Rifampicin [Internet]. 2019. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Rifampicin#section=Top
Ji B, Perani EG, Petinom C, N’Deli L, Grosset JH. Clinical trial of ofloxacin alone and in combination with dapsone plus clofazimine for treatment of lepromatous leprosy. Antimicrob Agents Chemother. 1994;38(4):662-7.
Rao PN, Jain S. Newer management option in leprosy. Indian J Dermatol. 2013;58(1): 6-11
Kusumastanto VA, Esti PK. Sindroma dapson pada pasien morbus hansen. CDK 2015;42(2)
Djuanda A. Ilmu penyakit kulit dan kelamin. 5th Ed. Jakarta: Fakultas Kedokteran Indonesia; 2007
Lockwiid, Diana NJ, Cunha, Maria DAG. Developing new MDT regimens for MB patient; Time to test ROM 12 months regimen globally. Lepr Rev. 2012;83:241-4
William DL, Gillis TP. Drug resistant - leprosy: Monitoring and current status. Lepr Rev. 2012;83:269-81
Drugs.com. Minocycline [Internet]. 2019. Available from: https://www.drugs.com/pro/minocycline.html
Basuki S, Rahmi M. Relapse of multibaccilary leprosy treated with rifampicin and ofloxacin: A case report. J Pigmentary Disorder. 2017
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