Mean Platelet Volume sebagai Faktor Prognostik Sepsis pada Anak
DOI:
https://doi.org/10.55175/cdk.v46i5.471Kata Kunci:
MPV, sepsisAbstrak
Sepsis adalah kondisi klinis disfungsi organ yang berpotensi mengancam nyawa. Skor Pediatric Logistic Organ Dysfunction 2 (PELOD-2) sering digunakan untuk memprediksi kematian pasien sepsis. Sebagian besar penelitian menemukan adanya peningkatan nilai MPV pada pasien sepsis, baik neonatus maupun dewasa. Nilai MPV dapat dijadikan salah satu parameter untuk menilai prognosis pasien sepsis.
Sepsis is a clinical condition of organ dysfunction that potentially life-threatening. Pediatric Logistic Organ Dysfunction 2 (PELOD-2) is used to predict mortality in patients with sepsis. Many studies found increased MPV value in sepsis (neonates and adults). MPV can become a prognostic parameter in sepsis
Unduhan
Referensi
Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2016.mIntensive Care Medicine.2017; 41(2): 580–637
Mayr FB, Yende S, Angus DC. Epidemiology of severe sepsis. Virulence 2014;5:4-11
Priyatiningsih DR, Latief A, Pudjiadi AH. Karakteristik sepsis di pediatric intensive care unit RSUPN dr. Cipto Mangunkusumo. Jakarta: Fakultas Kedokteran Universitas Indonesia; 2016.
Leteurtre S, Duhamel A, Salleron J, Grandbastien B, Lacroix J, Leclerc F; Groupe Francophone de Réanimation et d’Urgences Pédiatriques (GFRUP). PELOD-2: An update of the Pediatric Logistic Organ Dysfunction Score. Crit Care Med. 2013;41:761-73
Ware J, Corken A, Khetpal R. Platelet function beyond hemostasis and thrombosis. Curr Opin Hematol.m2013; 20: 451-56
Aziz M, Jacob A, Yang WL, Matsuda A, Wang P. Current trends in inflammatory and immunomodulatory mediators in sepsis. Journal of Leukocyte Biology. 2013;93: 329-42.
Singer M, Deutchman, Seymour CW. The third International consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801-10
Hadinegoro SRS, Chairulfatah A, Latief A, Pudjiadi AH, Malisie RF, Alam A. Pedoman nasional pelayanan kedokteran Ikatan Dokter Anak Indonesia: Diagnosis dan tatalaksana sepsis pada anak. Jakarta: Ikatan Dokter Anak Indonesia; 2016 .p. 1-7
Schulte W, Bernhagen J, Bucala R. Cytokines in sepsis: Potent immunoregulators and potential therapeutic targets - An updated view. Mediators of Inflammation [Internet]. 2013: 1-16. Available from: https://www.hindawi.com/journals/mi/2013/165974/
Ware J, Corken A, Khetpal R. Platelet function beyond hemostasis and thrombosis. Curr Opin Hematol .2013;20: 451-6
Bath P, Algert C, Chapman N, Neal B. Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease. Stroke 2004;35: 622-6
Graham SM, Conrad L. Platelets in sepsis: Beyond hemostasis. Blood. 2016;127(24): 2947-9
Zampieri FG, Ranzani OT, Sabatoski V, de Souza HP, Barbeiro H, da Neto LMC, et al. An increase in mean platelet volume after admission is associated with higher mortality in critically ill patients. Ann Intensive Care. 2014; 4: 20
Van der Lelie J, Von dem Borne AK. Increased mean platelet volume in septicaemia. J Clin Pathol. 1983;36(6):693-6
Becchi C, Al Malyan M, Fabbri LP, Marsili M, Boddi V, Boncinelli S. Mean platelet volume trend in sepsis: is it a useful parameter? Minerva Anestesiol. 2006;72(9):749-56
Oncel MY, Ozdemir R, Yurttutan S, Canpolat FE, Erdeve O, Oguz SS, et al. Mean platelet volume in neonatal sepsis. J Clin Lab Anal. 2012;26(6):493-6
Catal F, Tayman C, Tonbul A, Akça H, Kara S, Tatli MM, et al. Mean platelet volume (MPV) may simply predict the severity of sepsis in preterm infants. Clin Lab. 2014;60(7):1193-200
Gao Y, Li Y, Yu X, Guo S, Ji X, Sun T, et al. The impact of various platelet indices as prognostic markers of septic shock. Plos One. 2014;9(8):e103761
Gao Y, Li L, Li Y, Yu X, Sun T, Lan C. Change of platelet parameters in septic shock patients. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014;26(1):28-32
Kim JY, Yoon J, Lim CS, Choi BM, Yoon SY. Clinical significance of platelet-associated hematological parameters as an early supplementary diagnostic tool for sepsis in thrombocytopenic very-low-birth-weight infants. Platelet. 2015;26(7):620-6
Tajarernmuang P, Phrommintikul A, Limsukon A, Pothirat C, Chittawatanarat K. The role of mean platelet volume as a predictor of mortality in critically ill patients: A systematic review and meta analysis. Crit Care Res Pract. 2016;43:708-34
Ates S, Oksuz H, Dogu B, Bozkus F, Ucmak H, Yanit F. Can mean platelet volume and mean platelet volume/platelet count ratio be used as a diagnostic marker for sepsis and systemic inflammatory response syndrome? Saudi Med J. 2015;36(10):1186-90
Yao Y, Tu Y, Lu Q. Values of C-reactive protein, percentage of neutrophils and mean platelet volume in early diagnosis of neonatal sepsis. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17(5):425-9
Kim CH, Kim SJ, Lee MJ, Kwon YE, Kim YL, Park KS, et al. An increase in mean platelet volume from baseline is associated with mortality in patients with severe sepsis or septic shock. PloS One. 2015;10(3):30119437
Unduhan
Diterbitkan
Cara Mengutip
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2019 https://creativecommons.org/licenses/by-nc/4.0/
Artikel ini berlisensi Creative Commons Attribution-NonCommercial 4.0 International License.
