Obstetric Antiphospholipid Syndrome: Etiologi Keguguran Berulang yang Sulit Dikenali
DOI:
https://doi.org/10.55175/cdk.v46i5.473Kata Kunci:
Abortus, autoimun, sindrom antifosfolipid dalam kehamilanAbstrak
Keguguran atau abortus merupakan masalah yang dialami ibu hamil trimester pertama. Penyebabnya bervariasi dari kelainan kromosom hingga penyakit kronis ibu hamil. Obstetric antiphospholipid syndrome (OAS) merupakan penyakit autoimun yang dapat muncul dalam kehamilan, menyebabkan keguguran berulang sehingga menimbulkan beban medis, sosial, dan finansial yang besar. Pada kasus OAS murni tidak ada gejala lain; oleh karena itu, penting untuk dikenali.
Miscarriage or abortion is a complication in the first trimester pregnancy. The causes vary from chromosomal abnormalities to chronic diseases of pregnant women. Obstetric antiphospholipid syndrome (OAS) is an autoimmune disease that can happen in pregnancy, causing recurrent miscarriages resulting medical, social, and financial burdens. A pure OAS yields no other sign and symptoms aside from pregnancy complications such as recurrent miscarriage; it’s important to be recognized and managed.
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Referensi
Arachchillage DRJ, Machin SJ, Mackie IJ, Cohen H. Diagnosis and management of non-criteria antiphospholipid syndrome. Thromb Haemost 2015; 113:13-9
Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006;4(2):295–306 doi:10.1111/j.1538-7836.2006.01753
Giannakopoulos B, Krilis SA. The Pathogenesis of antiphospholipid syndrome. N Engl J Med 2013; 368 (11):1033-44
De Jesus GR, Agmon-Levin N, et al. 14th international congress on antiphospholipid antibodies task force report on obstetric antiphospholipid syndrome. Autoimmunity Rev 2014;13:795–813
De Jesus GR, Rodrigues G, De Jesus NR, Levy RA. Pregnancy morbidity in antiphospholipid syndrome : what is the impact of treatment ? Curr Rheumatol Rep 2014; 16:403-12
Levy RA, Dos Santos FC, De Jesus GR, De Jesus NR. Antiphospholipid antibodies and antiphospholipid syndrome during pregnancy : diagnostic concepts. Front. Immunol. 6:205. doi: 10.3389/fimmu.2015.00205
D’ippolito S, Meroni PL, Koike T, Veglia M, Scambia G, Di Simone N. Obstetric antiphospholipid syndrome : a recent classification for an old defined disorder. Autoimmunity Rev 2014; 13:901-8
Ruffatti A, Salvan E, Ross TD, et al. Treatment strategies and pregnancy outcomes in antiphospholipid syndrome patients with thrombosis and triple antiphospholipid positivity. Thromb Haemost 2014; 112:727-735.
Bramham K, Thomas M, Nelson-Piercy C, Khamashta M, Hunt BJ. First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss. Blood 2011;117:6948–51
Dendrinos S, Sakkas E, Makrakis E. Low-molecular-weight heparin versus intravenous immunoglobulin for recurrent abortion associated with antiphospholipid antibody syndrome. Int J Gynaecol Obstet 2009;104:223–5
Kronbichler A, Brenzina B, Quintana LF, Jayne DRW. Efficacy of plasma exchange and immunoadsorption in systemic lupus erythematosus and antiphospholipid syndrome : a systematic review. Autoimmun Rev 2015. Available at : http://dx.doi.org/ j.autrev.2015.08.010.
El-Haieg DO, Zanati MF, El-Foual FM. Plasmapheresis and pregnancy outcome in patients with antiphospholipid syndrome. Int J Gynaecol Obstet 2007; 99: 236-41
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