Promise of Synbiotic in Gut-Kidney Axis
DOI:
https://doi.org/10.55175/cdk.v51i1.617Kata Kunci:
Disbiosis, gut-kidney axis, mikrobiota, sinbiotikAbstrak
Mikrobiota manusia berperan menjaga kesehatan manusia pada kondisi seimbang. Perubahan komposisi mikroba akan menyebabkan ketidakseimbangan antara bakteri menguntungkan dan bakteri yang berpotensi merugikan, menyebabkan “disbiosis”. Hubungan patogenik antara mikrobiota usus dan penyakit ginjal disebut gut–kidney axis, yang berimplikasi pada berbagai manifestasi klinis seperti PGK (penyakit ginjal kronik), AKI (acute kidney injury), hipertensi, nefrolitiasis, nefropati IgA, hemodialisis, dan dialisis peritoneal. Sinbiotik, campuran probiotik dan prebiotik dilaporkan bermanfaat bagi kesehatan manusia melalui gut–kidney axis.
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DeGruttola AK, Low D, Mizoguchi A, Mizoguchi E. Current understanding of dysbiosis in disease in human and animal models. Inflammatory Bowel Dis. 2016;22(5):1137–50. DOI:10.1097/MIB.0000000000000750.
Yang T, Richards EM, Pepine CJ, Raizada MK. The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease. Nat Rev Nephrol. 2018;14(7):442–56. DOI: 10.1038/s41581-018-0018-2
Rukavina Mikusic NL, Kouyoumdzian NM, Choi MR. Gut microbiota and chronic kidney disease: Evidences and mechanisms that mediate a new communication in the gastrointestinal-renal axis. Pflügers Archiv - Eur J Physiol. 2020;472(3):303–20.
Stavropoulou E, Kantartzi K, Tsigalou C, Konstantinidis T, Romanidou G, Voidarou C, et al. Focus on the gut–kidney axis in health and disease. Front Med [Internet]. 2021;7. Available from: https://doi.org/10.3389/fmed.2020.620102.
Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: A randomized controlled trial. BMC Nephrol. 2022;23(1):259.
Yu Z, Zhao J, Qin Y, Wang Y, Zhang Y, Sun S. Probiotics, Prebiotics, and synbiotics improve uremic, inflammatory, and gastrointestinal symptoms in end-stage renal disease with dialysis: A network meta-analysis of randomized controlled trials. Front Nutr [Internet]. 2022;9. Available from: https://doi.org/10.3389/fnut.2022.850425.
Zheng HJ, Guo J, Wang Q, Wang L, Wang Y, Zhang F, et al. Probiotics, prebiotics, and synbiotics for the improvement of metabolic profiles in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2020;61(4):577–98. DOI: 10.1080/10408398.2020.1740645
Pavan M. Influence of prebiotic and probiotic supplementation on the progression of chronic kidney disease. Minerva Urol Nefrol. 2016;68(2):222-6.
Dai Y, Quan J, Xiong L, Luo Y, Yi B. Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: A systematic review and meta-analysis. Renal Failure 2022;44(1):862–80.
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