Efek Penambahan Laktulosa pada Susu Formula Bayi: Tinjauan Sistematik
DOI:
https://doi.org/10.55175/cdk.v45i11.697Kata Kunci:
Laktulosa, oligosakarida, prebiotik, susu formulaAbstrak
Pendahuluan: Salah satu komponen terbesar dalam air susu ibu (ASI) adalah oligosakarida. Oligosakarida berperan penting pada saluran cerna bayi melalui efek prebiotiknya. Laktulosa sebagai salah satu oligosakarida sintetis, telah dikategorikan sebagai prebiotik dan memiliki efek menyerupai ASI dalam hal mengubah komposisi mikrobiota usus. Metode: Tinjauan sistematis efek penambahan laktulosa ke dalam susu formula bayi. Hasil: Laktulosa bisa memperbaiki konsistensi dan frekuensi tinja, hingga menyerupai tinja bayi yang mendapat ASI. Efek samping campuran prebiotik yang sering ditemui adalah diare, kembung dan muntah. Simpulan: Masih diperlukan penelitian lebih lanjut untuk merekomendasikan penambahan laktulosa secara rutin pada susu formula bayi.
Introduction. One of the largest components of breast milk is human milk oligosaccharides (HMO). These components play an important role in the infant gastrointestinal tract based on their prebiotic effect. Lactulose is one of synthetic oligosaccharides, categorized as prebiotic; its effect resembles breastmilk in altering intestinal microbiota composition. Method. A systematic review on the effects of lactulose addition to infant formula. Results. Our search indicates that lactulose can improve the consistency and frequency of feces to resemble the stools of breast-fed infants. Adverse effects of mixed prebiotics are diarrhea, bloating and vomiting. Conclusion. Further research is still needed. Routine addition of lactulose in infant formula is not yet recommended.
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