Peningkatan Tekanan Intraokular pada Sindrom Nefrotik

Penulis

  • Harida Panduwita Sinaga Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Sumatera Utara/RSUP. H. Adam Malik, Medan, Indonesia
  • Rusdidjas Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Sumatera Utara/RSUP. H. Adam Malik, Medan, Indonesia
  • Rata Ramayati Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Sumatera Utara/RSUP. H. Adam Malik, Medan, Indonesia
  • Oke Rina Ramayani Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Sumatera Utara/RSUP. H. Adam Malik, Medan, Indonesia
  • Rosmayanti Siregar Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Sumatera Utara/RSUP. H. Adam Malik, Medan, Indonesia
  • Beatrix Siregar Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Sumatera Utara/RSUP. H. Adam Malik, Medan, Indonesia

DOI:

https://doi.org/10.55175/cdk.v45i8.738

Kata Kunci:

Anak, kortikosteroid, sindrom nefrotik, tekanan intraokular

Abstrak

Sindrom nefrotik (SN) merupakan penyakit ginjal terbanyak pada anak. Tatalaksana medikamantosa utama SN adalah menggunakan kortikosteroid; penggunaan dosis tinggi dan jangka lama dapat memiliki efek samping, salah satunya peningkatan tekanan intraokular. Mekanisme pasti peningkatan tekanan intraokular diinduksi steroid belum diketahui pasti, steroid dapat meningkatkan resistensi pengeluaran aqueous humor.

 

Nephrotic syndrome (NS) is the most common kidney disease in children. Corticosteroid is still preferred as primary treatment. High-dose and long term use of corticosteroids can increase intraocular pressure. The mechanism of steroid-induced increased intraocular pressure is not clearly understood; steroids can increase aqueous humor outflow resistance.

Unduhan

Data unduhan belum tersedia.

Referensi

Andolino TP, Adam JR. Nephrotic syndrome. Pediatrics in review. 2015;36(3):117-26.

Alatas H, Tambunan T, Trihono PP, Pardede SO. Konsensus tata laksana sindrom nefrotik idiopatik pada anak. Jakarta: IDAI; 2005 .p. 1-18.

Greenbaum LA, Benndorf R, Smoyer WE. Childhood nephritic syndrome-current and future therapies. Nat Rev Nephrol. 2012;8:445-58.

Wirya IG. Sindroma nefrotik. In: Alatas H, Tambunan T, Trihono PP, Pardede SO. Buku ajar nefrologi anak edisi 2. Jakarta: Balai Penerbit FK UI; 2002 .p. 381-422

Mandapati JS, Metta AK. Intraocular pressure variation in patient on long-term corticosteroid. Indian Dermatol online. 2011;2:67-9.

Ahmad M, Ahmed I, Ahmed W, Syed Z. Intraocular pressure; Incidence of steroid induced rise in local population of normal, V.K.C and C.S.G patient. Professional Med J. 2014;21(1):157-62

Brito PD, Silva SE, Cotta JS, Falcão-Reis F. Severe ocular hypertension secondary to systemic corticosteroid treatment in a child with nephrotic syndrome. Clin Ophthalmol. 2012;6:1675-9.

Rai VG, Sidhu T. Steroid-induced glaucoma. In: Maharana PK, Sharma N, Kumar A, editors. Ophthalmology clinics for postgraduates. New Delhi: Jaypee brothers; 2017 .p. 200-7.

Gaur S, Joseph M, Nityanandam S, Subramanian S, Koshy AS, Vasudevan A, et al. Ocular complication in children with nephroztic syndrome on longterm oral steroids. Indian J Pediatr. 2014;82:680-83.

Eva P, Whitcher JP. Vaughan & Asbury’s general pphthalmology 17th ed. United States: McGraw Hill; 2007 .Ch. 11

American Academy of Ophthalmology. Intraocular pressure and aqueous humor dynamic in: Glaucoma. San Fransisco: AAO; 2014 . p. 13-26.

Genis A. The effects of glucocorticoid on trabecular meshwork and its role in glaucoma. Am J Biochemistr Biotechnol. 2015;11:184-90.

Nuyen B, Weinreb R, Robbins SL. Steroid-induced glaucoma in the pediatric population. J AAPOS. 2017;21:1-6.

Lai CH, Fan DS, Chan JC. Corticosteroid-induced glaucoma in children. HKJ Ophthalmol [Internet]. Vol. 18(1):14-19. Available from: http://hkjo.hk/index.php/hkjo/article/viewFile/23/14

Jogi R. Glaucoma. Basic ophthalmology 4th ed. India: Jaypee Brothers Med Publ.; 2009 .p. 258-72.

Phulke A, Kaushik S, Kaur S, Pandav S. Steroid induced glaucoma: An avoidable irreversible blindness. J Curr Glaucoma Pract. 2017;2:67-72.

Alsaadi MM, Osuagwu UL, Almubrad TM. Effect of inhaled fluticasone on intraocular pressure and central corneal thickness in asthmatic children without a family history of glaucoma. Middle East African J Ophthalmol. 2012;19(3):314-9.

Ang M, Loh R, Zhang R, Tan D, Chan C, Ei Ti S. Steroid induced ocular hypertension in Asian children with severe vernal keratoconjunctivitis. 2012;6:1252-8.

Kaur S, Dhiman I, Kaushik S, Raj S, Pandav S. Outcome of ocular steroid hypertensive response in children. J Glaucoma. 2016;25:343-7.

Razeghinejad MR, Katz LJ. Steroid-induced iatrogenic glaucoma. Ophthalmic Res. 2012; 47:66-80.

Kawaguchi E, Ishikura K. Hamada R, Nagaoka Y, Morikawa Y, Sakai T, et al. Early and frequent development of ocular hypertension in children with nephrotic syndrome. Pediatr Nephrol. 2014;29:2165-71.

Martin E, Patrianakos T, Giovingo M. Medication induced glaucoma. Disease a month. 2017;63:54-7

Unduhan

Diterbitkan

2018-08-01

Cara Mengutip

Sinaga, H. P., Rusdidjas, Ramayati, R., Ramayani, O. R., Siregar, R., & Siregar, B. (2018). Peningkatan Tekanan Intraokular pada Sindrom Nefrotik. Cermin Dunia Kedokteran, 45(8), 597–599. https://doi.org/10.55175/cdk.v45i8.738

Terbitan

Vol 45 No 8 (2018): Dermatologi

Bagian

Articles

Lisensi

Hak Cipta (c) 2018 https://creativecommons.org/licenses/by-nc/4.0/

Creative Commons License

Artikel ini berlisensi Creative Commons Attribution-NonCommercial 4.0 International License.