Hubungan 25-hydroxyvitamin D dengan Sepsis pada Anak
DOI:
https://doi.org/10.55175/cdk.v45i6.777Kata Kunci:
25-hydroxyvitamin D, anak, sepsisAbstrak
Sepsis masih merupakan penyebab utama morbiditas dan mortalitas pada anak. Bukti terbaru menunjukkan bahwa vitamin D dapat meningkatkan respons imun bawaan dengan menginduksi peptida antimikroba. Pada anak, sepsis dijumpai adanya penurunan kadar 25-hydroxyvitamin D dan risiko sepsis meningkat pada pasien kekurangan vitamin D. Risiko mortalitas lebih tinggi pada pasien sepsis yang kekurangan vitamin D. Pemberian vitamin D pada anak dapat mengurangi keparahan penyakit dan menurunkan mortalitas.
Sepsis is a major cause of morbidity and mortality in pediatric population, despite scientific progresses in the last decades. Recent evidences suggest that vitamin D may enhance the innate immune response by induction of antimicrobial peptides. Children with sepsis have decreased 25-hydroxyvitamin D levels and vitamin D deficiency patients have increased sepsis risk. Vitamin D-deficient sepsis patients have higher risk of mortality compared to sepsis patients with normal vitamin D levels. Vitamin D supplementation may decrease the severity of illness and also reduce mortality.
Unduhan
Referensi
Latief A, Chairulfatah A, Alam A, Pudjiadi AH, Malisie RF, Hadinegoro SRS. Diagnosis dan tatalaksana sepsis pada anak. Ikatan Dokter Anak Indonesia; 2016.
Saraswati DD, Pudjiadi AH, Djer MM, Supriyatno B, Syarif DR, Kurniati N. Faktor risiko yang berperan pada mortalitas sepsis. Sari Pediatri 2014;15:281-8.
Hebbar KB, Wittkamp M, Alvarez JA, McCracken CE, Tangpricha V. Vitamin D deficiency in pediatric critical illness. J Clin Transl Endocrinol. 2014;1:170-5.
Grant WB. Solar ultraviolet-B irradiance and vitamin D may reduce the risk of septicemia. Dermatoendocrinol. 2009;1:37-42.
Braun A, Chang D, Mahadevappa K, Gibbons FK, Liu Y, Giovannucci E, et al. Association of low serum 25-hydroxyvitamin D levels and mortality in the critically ill. Crit Care Med. 2011;39:671-7.
Kempker JA, Han JE, Tangpricha V, Ziegler TR, Martin GS. Vitamin D and sepsis: An emerging relationship. Dermatoendocrinol. 2012;4:101-8.
Rech MA, Hunsaker T, Rodriguez J. Deficiency in 25-hydroxyvitamin D and 30-day mortality in patients with severe sepsis and septic shock. AJCC. 2014;23:72-9.
Aziz M, Jacob A, Yang WL, Matsuda A, Wang P. Current trends in inflammatory and immunomodulatory mediators in sepsis. J Leukoc Biol. 2013;93:329-42.
Rittirsch D, Flierl MA, Ward PA. Harmful molecular mechanisms in sepsis. Nat Rev Immunol. 2008;8:776-87.
van der Poll T, Opal SM. Host-pathogen interactions in sepsis. Lancet Infect Dis. 2008;8:32-43.
Schouten M, Wiersinga WJ, Levi M, van der Poll T. Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol. 2008;83:536-45.
Seeley EJ, Matthay MA, Wolters PJ. Inflection points in sepsis biology: From local defense to systemic organ injury. Am J Physiol Lung Cell Mol Physiol. 2012;303:355-63.
Schulte W, Bernhagen J, Bucala R. Cytokines in sepsis: Potent immunoregulators and potential therapeutic targets - An updated view. Mediators Inflamm. 2013;165974:1-16.
Cohen J. The immunopathogenesis of sepsis. Nature. 2002;420:885-91.
Nair R, Maseeh A. Vitamin D: The “sunshine” vitamin. J Pharmacol Pharmacother. 2012;3:118-26.
Walker VP, Modlin RL. The vitamin D connection to pediatric infections and immune function. Pediatr Res. 2009;65:106-13.
Jeng L, Yamshchikov AV, Judd SE, Blumberg HM, Martin GS, Ziegler TR, et al. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transl Med. 2009;7:28.
Ganji V, Zhang X, Tangpricha V. Serum 25-hydroxyvitamin D concentrations and prevalence estimates of hypovitaminosis D in the U.S. population based on assayadjusted data. J Nutr. 2012;142:498-507.
Lee JY, So TY, Thackray J. A review on vitamin D deficiency treatment in pediatric patients. J Pediatr Pharmacol Ther. 2013;18:277-91.
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911-30.
Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients 2013;5:2502-21.
Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D: Modulator of the immune system. Curr Opin Pharmacol. 2010;10:482-96.
Bartley J. Vitamin D: Emerging roles in infection and immunity. Expert Rev Anti Infect Ther. 2010;8:1359-69.
Yim S, Dhawan P, Ragunath C, Christakos S, Diamond G. Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D(3). J Cyst Fibros. 2007;6:403-10.
Hertting O, Holm Å, Lüthje P, Brauner H, Dyrdak R, Jonasson AF, et al. Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. PLoS One. 2010;5:e15580.
Adams JS, Hewison M. Unexpected actions of vitamin D: New perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008;4:80-90.
Hewison M. Vitamin D and the immune system: New perspectives on an old theme. Endocrinol Metab Clin North Am. 2010;39:365-79.
Speeckaert M, Huang G, Delanghe JR, Taes YE. Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta. 2006;372:33-42.
Zanetti M. Cathelicidins, multifunctional peptides of the innate immunity. J Leukoc Biol. 2004;75:39-48.
Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-81.
Moromizato T, Litonjua AA, Braun AB, Gibbons FK, Giovannucci E, Christopher KB. Association of low serum 25-hydroxyvitamin D levels and sepsis in the critically ill. Crit Care Med. 2014;42:97-107.
Ismail AM, Abdelrahman SH, Elsayed AH, Alkheshen GA, Sadaney MAE. A study of vitamin D status and cathelicidine plasma levels in pediatric population with sepsis. J Am Sci. 2015;11:1-6.
Madden K, Feldman HA, Smith EM, Gordon CM, Keisling SM, Sullivan RM, et al. Vitamin D deficiency in critically ill children. Pediatrics. 2012;130:1-8.
Cetinkaya M, Cekmez F, Buyukkale G, Ercan TE, Demir F, Tunc T. Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants. J Perinatol. 2015;35:39-45.
Satheesh P, Verma S, Singhi S, Bansal A. Prevalence of vitamin D deficiency among children with sepsis, its association with sepsis severity and its outcome in a pediatric ICU. Crit Care. 2013;17:35.
Unduhan
Diterbitkan
Cara Mengutip
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2018 https://creativecommons.org/licenses/by-nc/4.0/
Artikel ini berlisensi Creative Commons Attribution-NonCommercial 4.0 International License.
