Peranan Sel Punca dalam Penyembuhan Luka
DOI:
https://doi.org/10.55175/cdk.v45i5.790Kata Kunci:
Mesenchymal stem cells, terapi sel, wound healingAbstrak
Penyembuhan luka yang optimal melibatkan berbagai proses biologi dan molekuler berupa migrasi sel, proliferasi, deposisi matriks ekstraseluler, dan remodelling. Berbagai pendekatan penelitian berbasis sel dapat membantu penggunaan sel punca (stem cells) untuk mempercepat proses penyembuhan luka. Tinjauan ini mengenai tipe sel punca yang dapat digunakan untuk penyembuhan luka namun penggunaan klinisnya masih terbatas.
Optimal wound healing includes various biological and molecular processes. Adult stem cells can promote more effective wound therapy. Choosing the right stem cells through in vivo study is important. Further studies is needed for the identification of appropriate adult stem cells, protocols, and building the bioscaffold used for optimal wound healing in the future.
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Referensi
8asitaatmadja SM. Anatomi kulit. In Djuanda A, Hamzah M, Aisah S, editors. Ilmu penyakit kulit dan kelamin. 5th Ed. Jakarta: FKUI; 2010. p. 3.
Nkemcho O, Irena P, Marjana TC, Olivera S. Stem cells in skin regeneration. Int J Mol Sci. 2015;16:25476-501.
Kirby GTS, Mills SJ, Cowin AJ, Smith LE. Stem cells for cutaneous wound healing. BioMed Res Internat. 2015;2015:11.
Saputra V. Dasar-dasar stem cell dan potensi aplikasinya dalam ilmu kedokteran. CDK. 2006;153:1-2.
The National Institutes of Health. Stem cells basics . 2015. Available from https://stemcells.nih.gov/info/basics.htm
Yolanda MM, Maria A7, Amaia F(, Marcos PB, Silvia PL, Dolores E, et al. Adult stem cell therapy in chronic wound healing. J Stem Cell Res Ther. 2014;4:1.
Duscher D, Barrera J, 8ong 7, Maan ;N, 8hittam AJ, Januszyk M, et al. Stem cells in wound healing The future of regenerative medicine A mini review. Gerontol. 2016;62:216-25.
Maxson S, Lopez EA, :oo D, Danilkovitch-Miagkova A, Leroux MA. Concise review: Role of mesenchymal stem cells in wound repair. Stem Cells Translat Med. 2012;1:142-9.
Lee DE, Ayoub N, Agrawal DK. Mesenchymal stem cells and cutaneous wound healing Novel methods to increase cell delivery and therapeutic efficacy. Stem Cell Res Ther. 2016;7:37.
Studying adult stem cells during cancer . 2010. Available from http://blanpainlab.ulb.ac.be/research@02.html
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