Kejadian Mual Muntah Pasca-Laparatomi (PONV) setelah Pemberian Granisetron Dibandingkan setelah Pemberian Kombinasi Ondansetron - Deksametason
DOI:
https://doi.org/10.55175/cdk.v45i3.813Kata Kunci:
Deksametason, granisetron, laparatomi, ondansetron, PONVAbstrak
Pendahuluan: Mual muntah pasca-operasi (PONV) adalah pengalaman tidak menyenangkan yang sering dialami pasien setelah menjalani operasi dengan anestesi umum seperti laparatomi. Metode: Penelitian desain eksperimental tersamar tunggal; 58 subjek yang menjalani laparatomi dengan anestesi umum dibagi menjadi 2 kelompok secara acak. Kelompok I diberi granisetron 1 mg, 30 sampai 60 menit sebelum operasi selesai, kelompok II diberi deksametason 8 mg sebelum induksi dan ondansetron 4 mg, 30 sampai 60 menit sebelum operasi selesai. Kejadian PONV semua pasien diamati selama 24 jam. Hasil: Pada kelompok I mampu dicegah 72,4% kejadian PONV, pada kelompok II mampu dicegah 79,3% kejadian PONV. Simpulan: Tidak ada perbedaan bermakna manfaat ondansetron 4 mg dan deksametason 8 mg dibanding granisetron 1 mg dalam mencegah mual muntah pasca-laparatomi.
Introduction: Post operative nausea and vomiting (PONV) is usually experienced after laparatomy with general anesthesia. Methods: A single blind experimental design; 58 subject underwent laparatomy with general anesthesia were randomly divided into 2 groups. Group I received 1 mg granisetron, 30 to 60 minutes before the end of surgery, and group II received 8 mg dexamethasone before anesthesia induction and were given 4 mg ondansetron, 30 to 60 minutes before the end of surgery. All patients were observed for PONV until 24 hours post surgery. Result: In group I PONV could be prevented in 72,4% subject whereas in group II PONV could be prevented in 79,3% subject. Conclusion: No significant difference of efficacy between 4 mg ondansetron and 8 mg dexamethasone, compared to 1 mg granisetron in preventing post laparatomy PONV.
Unduhan
Referensi
Morgan GE, Mikhail MS, Murray MJ. Nausea and vomiting. In: Clinical anesthesiology. 4th ed. New York: Lange Medical Book; McGraw-Hill Co.; 2006. p.1004-8.
Wilks DH. Postoperative nausea and vomiting. In: Decision making in anesthesiology. 3rd ed. Philadelphia: Mosby; 2000. p.596-7.
Gupta V, Wakloo R, Lahori VU, Mahajan MK. Prophylactic antiemetic therapy with ondancetron, granicetron, and metochlorpramide in patients undergoing laparascopic cholecyctectomy under general anesthesia. The Internet J Anesthesiol. 2007;1:1-5.
Saeda I. Post operative nausea and vomiting (PONV): A review article. Indian J Anesth. 2004;1:253-8.
Gan TJ, Meyer T, Apfel CC, Chung F, Davis PJ, Eubanks S, et al. Concencus for managing post operative nausea and vomiting. Anesth Analgesia. 2003;97:62-71.
Wallenborn J, Gelbrich G, Bulst D, Behrends K, Rohrbach A, Krause U, et al. Prevention of postoperative nausea and vomiting by granicetron combined with dexamethasone: Randomized double blind multicentre Trial. BMJ. 2006;333:324-41.
Wells BG, Dipiro JT, Shwinghammer TL, Hamilton CW. Pharmacotherapy. 5th ed. Philadelphia: McGraw-Hill; 2003. p.247-52.
Ting PH. Post operative nausea and vomiting (PONV): An overview [Internet]. 2004. Available from: www.anesthesiologinfo.com/articles/0425204.php-27k
Hanaoka K, Toyooka H, Kugimiya T, Ohashi. Efficacy of prophylactic intravenous granicetron in post operative emesis in adults. J Anesth. 2004;18:58-65.
Fuji Y, Nakayama M. Dexamethasone for reduction of nausea, vomiting, and analgesic use after gynecological laparascopic surgery. Internat J Gynecol Obstetr. 2008;100:27-30.
Dua N, Bhatnagar S, Mishra S, Singhal AK. Granicetron and ondancetron for prevention of nausea and vomiting in patients undergoing modified radical mastectomy. Anesthesia Intensive Care 2004;32:74-6.
Janicki PK. A meta analysis of the efficacy and safety of granicetron 0,1 mg for post operative nausea and vomiting. The Internet J Anesthesiol. 2007;4:15-9.
Goldman G. The pharmacological basic of therapeutics. 10th ed. Boston: McGraw-Hill; 2001. p.344-7.
Dipasri B, Arnab B. Comparison of ondancetron and granicetron for prevention of nausea and vomiting following day care gynaecological laparascopy. Indian J Anesthesiol. 2003;47:279-84.
Smith DB, Newlands ES, Rustan GJ, Begent RH, Howells N, McQuade B, Bagshawe KD. Comparison of ondancetron and ondancetron plus dexamethasone as antiemetic prophylaxis during cisplatin containing chemotherapy. Br J Anesthesiol. 1997;78:247-55.
Kang KL, Hsu CC, Chia YY. The effective dose of dexamethasone for antiemetic after mayor gynaecological surgery. Anesthesia & Analgesia. 1999;89:1316.
Habib AS, Gan TJ. Evidence based management of post operative nausea and vomiting: A review. Canad J Anesth. 2004;5:326-41.
Stoelting RK. Pharmalogy and physiology in anesthesia practice. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2006. p.444-8.
Pang WW, Wu HS, Lin CH, Chang DP, Huang MH. Metochlorpramide decreases emesis but increase sedation in tramadol patient-controlled analgesia. Canadian J Anesth. 2002;49:1029-33.
Dewoto HR, Lousia M. Serotonin, obat serotoninergik, dan obat antiserotoninergik. In: Farmakologi dan terapi. 5th ed. Jakarta: Fakultas Kedokteran Universitas Indonesia; 2007. p.288-98.
Unduhan
Diterbitkan
Cara Mengutip
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2018 https://creativecommons.org/licenses/by-nc/4.0/
Artikel ini berlisensi Creative Commons Attribution-NonCommercial 4.0 International License.
