Clinical Characteristics, Chest X-Ray and Laboratory Findings of COVID-19 Patients in Leona Kefamenanu Hospital on 2021 : A retrospective study
DOI:
https://doi.org/10.55175/cdk.v50i12.947Kata Kunci:
COVID-19, Karakteristik klinis, dispnea, kelelahan, kelompok usia lebih lanjutAbstrak
Pendahuluan: COVID-19 dapat mengancam jiwa pasien kelompok usia lebih lanjut dan yang memiliki penyakit penyerta. Penelitian ini mengenai karakteristik klinis pasien infeksi COVID-19 yang dirawat di rumah sakit di pedalaman di Indonesia. Metode: Penelitian retrospektif noneksperimental pasien COVID-19 yang dirawat di rumah sakit Leona Kefamenanu, Nusa Tenggara Timur, Indonesia, dari Januari hingga Desember 2021. Analisis regresi logistik multivariat digunakan untuk mengidentifikasi faktor penyebab COVID-19 berat. Hasil: Dari 153 pasien, 66 (43,1%) laki-laki, sebagian besar berusia 40 sampai 59 tahun. Gejala paling sering adalah batuk 144 (94,1%), diikuti demam (n= 105, 68,9%), kelelahan/fatigue (n=92, 60,1%), dan mual (n= 80, 52,3%). Sebagian besar pasien memiliki hasil leukosit, limfosit, dan trombosit normal. Hipokalemia pada 17,6% pasien, lebih sering pada pasien dengan derajat berat (p <0,029). Sebagian besar pasien memiliki kelainan pada rontgen dada saat masuk (63,4%) yang semuanya COVID-19 derajat berat. Analisis regresi logistik multivariat menunjukkan bahwa usia ≥60 tahun (OR = 8,98; 95%CI:1,81–44,56; p =0,007) dan sesak napas atau dispnea (OR = 16,83; 95%CI: 1,95–144,69; p =0,010) secara independen terkait dengan derajat keparahan COVID-19. Fatigue (OR = 4,606; 95% CI: 1,589–13,354; p <0,005) juga berhubungan secara independen dengan perburukan penyakit. Simpulan: Usia ≥60 tahun, kelelahan/fatigue, dan dispnea dikaitkan dengan keparahan COVID-19 di RS Leona Kefamenanu, Nusa Tenggara Timur, Indonesia.
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Referensi
Setiadi W, Rozi IE, Safari D, Daningrat WOD, Johar E, Yohan B, et al. Prevalence and epidemiological characteristics of COVID-19 after one year of pandemic in Jakarta and neighbouring areas, Indonesia: A single center study. PLoS One 2022;17(5):e0268241.
Sharma K, Aggarwala P, Gandhi D, Mathias A, Singh P, Sharma S, et al. Comparative analysis of various clinical specimens in detection of SARS-CoV-2 using rRT-PCR in new and follow up cases of COVID-19 infection: Quest for the best choice. PLoS One 2021;16(4):e0249408..
Goyal P, Choi JJ, Pinheiro LC, Schenck EJ, Chen R, Jabri A, et al. Clinical characteristics of Covid-19 in New York City. New England Journal of Medicine 2020;382(24):2372–4.
.Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di Napoli R. Features, evaluation, and treatment of Coronavirus (COVID-19) [Internet]. 2022 Jun 30 [cited 2022 Aug 3]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554776/
Parasher A. COVID-19: Current understanding of its pathophysiology, clinical presentation and treatment. Postgrad Med J. 2021;97(1147):312–20.
Gong X, Kang S, Guo X, Li Y, Gao H, Yuan Y. Associated risk factors with disease severity and antiviral drug therapy in patients with COVID-19. BMC Infect Dis. 2021;21(1):549.
Guo T, Fan Y, Chen M, Wu X, Zhang L, He T, et al. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). JAMA Cardiol. 2020;5(7):811–8.
Zhu J, Zhong Z, Ji P, Li H, Li B, Pang J, et al. Clinicopathological characteristics of 8697 patients with COVID-19 in China: A meta-analysis. Fam Med Com Health 2020;8:406.
Abougazia A, Alnuaimi A, Mahran A, Ali T, Khedr A, Qadourah B, et al. Chest X-ray findings in COVID-19 patients presenting to primary care during the peak of the first wave of the pandemic in Qatar: Their association with clinical and laboratory findings. Pulm Med. 2021 Oct 27:2021:4496488.
Rousan LA, Elobeid E, Karrar M, Khader Y. Chest x-ray findings and temporal lung changes in patients with COVID-19 pneumonia [Internet]. 2020 [cited 2023 Feb 28]. Available from: https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-020-01286-5
Sofic A, Cizmic M, Beslagic E, Becirevic M, Mujakovic A, Selimovic AH, et al. Brixia chest x-ray severity scoring system is in relation with C-reactive protein and D-dimer values in patients with COVID-19. Mater Sociomed. 2022;34(2):95.
Burhan E, Dwi Susanto A, Nasution SA, Ginanjar E, Wicaksono Pitoyo C, Susilo A, et al. Protokol tatalaksana COVID-19. Perhimpunan Dokter Paru Indonesia (PDPI) Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI) Perhimpunan Dokter Spesialis Penyakit Dalam Indonesia (PAPDI) Perhimpunan Dokter Anestesiologi dan Terapi Intensif Indonesia (PERDATIN) Ikatan Dokter Anak Indonesia (IDAI); 2020.
Burhan E, Dwi Susanto A, Nasution SA, Ginanjar E, Wicaksono Pitoyo C, Susilo A, et al. Pedoman tatalaksana COVID-19. 2nd Ed [Internet]. 2020. Available from: https://www.papdi.or.id/pdfs/938/Pedoman%20Tatalaksana%20COVID-19%20edisi%202.pdf
Burhan E, Dwi Susanto A, Isbaniah F, Aman Nasution S, Ginanjar E, Wicaksono Pitoyo C, et al. Pedoman tatalaksana COVID-19. 3rd Ed. Perhimpunan Dokter Paru Indonesia (PDPI) Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI) Perhimpunan Dokter Spesialis Penyakit Dalam Indonesia (PAPDI) Perhimpunan Dokter Anestesiologi dan Terapi Intensif Indonesia (PERDATIN) Ikatan Dokter Anak Indonesia (IDAI); 2020.
Leulseged TW, Hassen IS, Edo MG, Abebe DS, Maru EH, Zewde WC, et al. Duration of supplemental oxygen requirement and predictors in severe COVID-19 patients in Ethiopia: A survival analysis. Ethiop J Health Sci. 2021;31(4):699.
Wu Y, Ding Y, Tanaka Y, Zhang W. Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. Internat J Med Sci. 2014;11:1185–200.
Tadic M, Saeed S, Grassi G, Taddei S, Mancia G, Cuspidi C. Hypertension and COVID-19: Ongoing controversies. Front Cardiovasc Med. 2021;8:639222.
Ukena D, Fishman L, Niebling WB. Bronchial asthma: Diagnosis and long-term treatment in adults. Dtsch Arztebl Int. 2008;105(21):385.
Russell CD, Lone NI, Baillie JK. Comorbidities, multimorbidity and COVID-19. Nature Med. 2023;29(2):334–43.
Org WK, Kasiske B, City M. Kidney disease: improving global outcomes guideline on CKD [Internet]. 2014. Available from: www.kdigo.org
.Ibrahim ME, AL-Aklobi OS, Abomughaid MM, Al-Ghamdi MA. Epidemiological, clinical, and laboratory findings for patients of different age groups with confirmed coronavirus disease 2019 (COVID-19) in a hospital in Saudi Arabia. PLoS One 2021;16(4):e0250955.
Meister T, Pisarev H, Kolde R, Kalda R, Suija K, Milani L, et al. Clinical characteristics and risk factors for COVID-19 infection and disease severity: A nationwide observational study in Estonia. PLoS One 2022;17(6):e0270192.
Pandita A, Gillani FS, Shi Y, Hardesty A, McCarthy M, Aridi J, et al. Predictors of severity and mortality among patients hospitalized with COVID-19 in Rhode Island. PLoS One 2021;16(6):e0252411.
Chen H, Qin L, Wu S, Xu W, Gao R, Zhang X. Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study. PLoS One 2021 May 18;16(5):e0249964.
Zhang H, Du F, Cao XJ, Feng XL, Zhang HP, Wu ZX, et al. Clinical characteristics of coronavirus disease 2019 (COVID-19) in patients out of Wuhan from China: A case control study. BMC Infect Dis. 2021;21(1):207.
Kaeuffer C, Le Hyaric C, Fabacher T, Mootien J, Dervieux B, Ruch Y, et al. Clinical characteristics and risk factors associated with severe COVID-19: Prospective analysis of 1,045 hospitalised cases in North-Eastern France, March 2020. Eurosurveillance 2020;25(48):1.
Dhont S, Derom E, Van Braeckel E, Depuydt P, Lambrecht BN. The pathophysiology of “happy” hypoxemia in COVID-19. Respir Res. 2020;21(1):1–9.
Dennis JM, Mateen BA, Sonabend R, Thomas NJ, Patel KA, Hattersley AT, et al. Type 2 diabetes and COVID-19–related mortality in the critical care setting: A national cohort study in England, March–July 2020. Diabetes Care 2021;44(1):50.
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. The Lancet 2020;395(10223):507–13.
Yin J, Yuan N, Huang Z, Hu Z, Bao Q, Shao Z, et al. Assessment of hypokalemia and clinical prognosis in patients with COVID-19 in Yangzhou, China. PLoS One 2022;17(7):e0271132.
Moreno-P O, Leon-Ramirez JM, Fuertes-Kenneally L, Perdiguero M, Andres M, Garcia-Navarro M, et al. Hypokalemia as a sensitive biomarker of disease severity and the requirement for invasive mechanical ventilation requirement in COVID-19 pneumonia: A case series of 306 Mediterranean patients. Internat J Infect Dis. 2020;100:449–54.
Hafiz M, Icksan AG, Harlivasari AD, Aulia R, Susanti F, Eldinia L. Clinical, radiological features and outcome of COVID-19 patients in a secondary Hospital in Jakarta, Indonesia. J Infect Dev Countries. 2020;14(7):750–7.
Sterne JAC, Murthy S, Diaz JV, Slutsky AS, Villar J, Angus DC, et al. Association between administration of systemic corticosteroids and mortality among critically ill patients with COVID-19: A meta-analysis. JAMA. 2020;324(13):1330–41.
Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. Journal of Thrombosis and Haemostasis 2020; 18(5): 1094.
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