Flecainide sebagai Antiaritmia untuk Fibrilasi Atrium dan Aritmia Lainnya
DOI:
https://doi.org/10.55175/cdk.v51i4.948Kata Kunci:
Antiaritmia, fibrilasi atrium, flecainide, kontrol iramaAbstrak
Fibrilasi atrium (atrial fibrillation/AF) merupakan jenis aritmia yang paling sering terjadi di seluruh dunia, dengan prevalensi yang diproyeksikan terus meningkat, termasuk di Indonesia. Progresi AF berkaitan dengan penurunan kualitas hidup dan seiring berjalannya waktu menjadi kurang responsif terhadap terapi atau bahkan menjadi irreversible. Progresi AF diketahui secara signifikan lebih rendah dengan strategi kontrol irama dibandingkan kontrol laju saja. Di Indonesia, pilihan obat masih terbatas pada amiodarone dan propafenone; amiodarone merupakan salah satu obat yang paling umum digunakan untuk kendali irama AF tetapi berhubungan dengan toksisitas organ multipel terutama pada penggunaan jangka panjang, berpotensi menyebabkan dihentikannya terapi. Flecainide merupakan antiaritmia dengan efektivitas dan profil keamanan yang baik, khususnya untuk terapi AF, kardioversi akut, kontrol irama jangka panjang, serta terapi AF dengan sindrom preeksitasi. Flecainide berpotensi dapat menanggulangi unmet needs dari amiodarone sebagai terapi AF jangka panjang. Selain itu, flecainide juga berperan dalam terapi supraventricular tachycardia (SVT) dan ventricular tachycardia (VT).
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