Anti-Epileptic Drug (OAE) Selection for Women with Epilepsy of Childbearing Age
Literature Review
DOI:
https://doi.org/10.55175/cdk.v52i1.1121Keywords:
Epilepsy, anti-epileptic drugs, women with epilepsyAbstract
Epilepsy is the most common chronic brain disorder and can affect people of all ages. Globally, an estimated 60 million people are diagnosed with epilepsy, half of whom are women, and about a third of women with epilepsy are of childbearing age. The main therapy for epilepsy is anti-epileptic drugs to control epileptic seizures. In Indonesia, first-line anti-epileptic drugs are carbamazepine, valproic acid, phenobarbital, and phenytoin, while second-line anti-epileptic drugs are lamotrigine, levetiracetam, clobazam, and topiramate. There are many concerns when women with epilepsy start planning a pregnancy, especially regarding the effect of epilepsy drugs on pregnancy and their effects on the fetus, such as teratogenic effects, neonatal outcomes, and neurodevelopmental impacts. The choice of anti-epileptic drugs (AEDs) in women of childbearing age must be considered carefully.
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References
Kusumastuti K. Pedoman tatalaksana epilepsi. 6th Ed. Surabaya: Airlangga; 2019.
World Health Organization. Epilepsy [Internet]. [cited 2023 Oct 18]. Available from: https://www.who.int/news-room/fact-sheets/detail/epilepsy.
Błaszczyk B, Miziak B, Pluta R, Czuczwar SJ. Epilepsy in pregnancy-Management principles and focus on valproate. Internat J Mol Sci. 2022;23(3):1369. DOI: 10.3390/ijms23031369.
Meador KJ, Loring DW. Developmental effects of antiepileptic drugs and the need for improved regulations. Neurology 2016;86(3):297-306. DOI: 10.1212/WNL.0000000000002119.
Arifputra A, Sumantri FO. Epilepsi. In: Arifputra A, editor. Kapita selekta kedokteran. 2nd Ed. Jakarta: Media Aesculapius; 2014.
Persatuan Dokter Spesialis Saraf Indonesia. Pedoman tatalaksana epilepsi. 4th Ed. Jakarta: PERDOSSI; 2011. p. 3-28.
Karbamazepin [Internet]. [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/karbamazepin.
Jentink J, Dolk H, Loane MA, Morris JK, Wellesley D, Garne E, et al. Intrauterine exposure to carbamazepine and specific congenital malformations: Systematic review and case-control study. BMJ 2010;341:c6581. DOI:10.1136/ bmj.c6581.
King A, Gerard EE. Contraception, fecundity, and pregnancy in women with epilepsy: An update on recent literature. Curr Opin Neurol. 2022;35(2):161–8. DOI: 10.1097/wco.0000000000001039.
Weston J, Bromley R, Jackson CF, Adab N, Clayton-Smith J, Greenhalgh, et al. Monotherapy treatment of epilepsy in pregnancy: Congenital malformation outcomes in the child. Cochrane Database of Systematic Rev. 2016;11(11):CD010224. DOI: 10.1002/14651858.CD010224.pub2.
Phenobarbital [Internet]. [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/phenobarbital.
Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Sabers A, et al. Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol 2011;10(7):609–17. DOI: 10.1016/S1474-4422(11)70107-7.
Voinescu PE, Pennell PB. Management of epilepsy during pregnancy. Expert Rev Neurother. 2015;15(10):1171–87. DOI: 10.1586/14737175.2015.1083422.
Phenytoin [Internet]. [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/phenytoin.
Khuda I, Aljaafari D. Epilepsy in pregnancy. Neurosciences. 2018;23(3):185–93. DOI:10.17712/nsj.2018.3.20180129.
Valproic acid [Internet]. [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/valproic-acid.
Veroniki AA, Cogo E, Rios P, Straus SE , Finkelstein Y, Kealey R, et al. Comparative safety of anti-epileptic drugs during pregnancy: A systematic review and network meta-analysis of congenital malformations and prenatal outcomes. BMC Med. 2017;15:95. DOI: 10.1186/s12916-017-084.
Gov.UK. Valproate use by women and girls [Internet]. 2018 [cited 2023 Oct 29]. Available from: https://www.gov.uk/guidance/valproate-use-bywomen-and-irls#contents.
Thomas RH. Valproate: Life-saving, life-changing. Clin. Med. 2018;18:1–8. DOI: 10.7861/clinmedicine.18-2-s1.
Huber-Mollema Y, Oort FJ, Lindhout D, Rodenburg R. Well-being of mothers with epilepsy with school-aged children. Epilepsy Behav. 2020;105:106966. DOI: 10.1016/j.yebeh.2020.106966.
Wiggs KK, Rickert ME, Sujan AC, Quinn PD, Larsson H, Lichtenstein P. Antiseizure medication use during pregnancy and risk of ASD and ADHD in children. Neurology 2020;95:3232–40. DOI: 10.1212/WNL.0000000000010993.
Morrell MJ, Hayes FJ, Sluss PM, Adams JM, Bhatt M, Ozkara C, et al. Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine. Ann Neurol. 2008;64:200–11. DOI: 10.1002/ana.21411.
Lamotrigine [Internet]. [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/lamotrigine.
Antiepileptic drugs: Review of safety of use during pregnancy. MHRA UK Public Assessment Report [Internet]. 2021 [cited 2023 Nov 4]. Available from:
Polepally A, Pennell P, Brundage R, Stowe ZN, Newport DJ, Viguera AC, et al. Model-based lamotrigine clearance changes during pregnancy: Clinical implication. Ann Clin Translat Neurol. 2014;1(2):99–106. DOI: 10.1002/acn3.29.
Madley Dowd P, Rast J, Ahlqvist VH, Zhong C, Martin FZ, Davies NM, et al. Trends and patterns of antiseizure medication prescribing during pregnancy between 1995 and 2018 in the United Kingdom: A cohort study. BJOG. 2024 Jan;131(1):15-DOI: 10.1111/1471-0528.17573.
Levetiracetam [Internet]. [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/levetiracetam.
Dupont S, Vercueil L. Epilepsy and pregnancy: What should the neurologists do? Rev Neurol. 2021;177(3):168–79. DOI:10.1016/j.neurol.2021.01.003.
Clobazam [Internet]. [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/clobazam.
Jensen AG, Knudsen SS, Bech BH. Prenatal exposure to benzodiazepines and the development of The offspring – A systematic review. Neurotoxicol Teratol. 2022;91:107078. DOI:10.1016/j.ntt.2022.107078.
Topiramate [Internet]. 2023 [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/topiramate.
Bjork MH, Zoega H, Leinonen MK, Cohen JM, Dreier JW, Furu K, et al. Association of prenatal exposure to antiseizure medication with risk of autism and intellectual disability. JAMA Neurology 2022;79(7): 672–81. DOI: 1001/jamaneurol.2022.1269.
Gooneratne IK, Wimalaratna M, Ranaweera AK, Wimalaratna S. Contraception advice for women with epilepsy. BMJ. 2017;357:j2010. DOI:10.1136/bmj.j2010.
Li Y, Meador KJ. Epilepsy and Pregnancy. CONTINUUM Lifelong Learning in Neurology 2022 Feb 1;28(1):34-54. DOI: 10.1212/CON.0000000000001056.
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