Pemilihan Obat Anti-Epilepsi (OAE) untuk Penyandang Epilepsi Wanita Usia Subur
Tinjauan Pustaka
DOI:
https://doi.org/10.55175/cdk.v52i1.1121Kata Kunci:
Epilepsi, obat anti-epilepsi, wanita dengan epilepsiAbstrak
Epilepsi merupakan gangguan kronis pada otak yang paling umum dan dapat menyerang seluruh usia. Secara global, diperkirakan 60 juta orang didiagnosis mengalami epilepsi, setengahnya adalah wanita, dan sekitar sepertiga wanita penderita epilepsi berada pada usia subur. Terapi utama epilepsi adalah obat anti-epilepsi yang bertujuan untuk mengontrol bangkitan epilepsi. Di Indonesia, obat anti-epilepsi lini pertama adalah carbamazepine, valproic acid, phenobarbital, dan phenytoin, sedangkan obat anti-epilepsi lini kedua adalah lamotrigine, levetiracetam, clobazam, dan topiramate. Banyak kekhawatiran saat wanita dengan epilepsi mulai merencanakan kehamilan, terutama mengenai pengaruh obat–obat epilepsi terhadap kehamilan dan efeknya terhadap janin, seperti efek teratogenik, outcome neonatal, dan dampak perkembangan saraf. Pemilihan obat anti-epilepsi (OAE) untuk wanita subur harus dipertimbangkan dengan hati-hati.
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Referensi
Kusumastuti K. Pedoman tatalaksana epilepsi. 6th Ed. Surabaya: Airlangga; 2019.
World Health Organization. Epilepsy [Internet]. [cited 2023 Oct 18]. Available from: https://www.who.int/news-room/fact-sheets/detail/epilepsy.
Błaszczyk B, Miziak B, Pluta R, Czuczwar SJ. Epilepsy in pregnancy-Management principles and focus on valproate. Internat J Mol Sci. 2022;23(3):1369. DOI: 10.3390/ijms23031369.
Meador KJ, Loring DW. Developmental effects of antiepileptic drugs and the need for improved regulations. Neurology 2016;86(3):297-306. DOI: 10.1212/WNL.0000000000002119.
Arifputra A, Sumantri FO. Epilepsi. In: Arifputra A, editor. Kapita selekta kedokteran. 2nd Ed. Jakarta: Media Aesculapius; 2014.
Persatuan Dokter Spesialis Saraf Indonesia. Pedoman tatalaksana epilepsi. 4th Ed. Jakarta: PERDOSSI; 2011. p. 3-28.
Karbamazepin [Internet]. [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/karbamazepin.
Jentink J, Dolk H, Loane MA, Morris JK, Wellesley D, Garne E, et al. Intrauterine exposure to carbamazepine and specific congenital malformations: Systematic review and case-control study. BMJ 2010;341:c6581. DOI:10.1136/ bmj.c6581.
King A, Gerard EE. Contraception, fecundity, and pregnancy in women with epilepsy: An update on recent literature. Curr Opin Neurol. 2022;35(2):161–8. DOI: 10.1097/wco.0000000000001039.
Weston J, Bromley R, Jackson CF, Adab N, Clayton-Smith J, Greenhalgh, et al. Monotherapy treatment of epilepsy in pregnancy: Congenital malformation outcomes in the child. Cochrane Database of Systematic Rev. 2016;11(11):CD010224. DOI: 10.1002/14651858.CD010224.pub2.
Phenobarbital [Internet]. [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/phenobarbital.
Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Sabers A, et al. Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol 2011;10(7):609–17. DOI: 10.1016/S1474-4422(11)70107-7.
Voinescu PE, Pennell PB. Management of epilepsy during pregnancy. Expert Rev Neurother. 2015;15(10):1171–87. DOI: 10.1586/14737175.2015.1083422.
Phenytoin [Internet]. [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/phenytoin.
Khuda I, Aljaafari D. Epilepsy in pregnancy. Neurosciences. 2018;23(3):185–93. DOI:10.17712/nsj.2018.3.20180129.
Valproic acid [Internet]. [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/valproic-acid.
Veroniki AA, Cogo E, Rios P, Straus SE , Finkelstein Y, Kealey R, et al. Comparative safety of anti-epileptic drugs during pregnancy: A systematic review and network meta-analysis of congenital malformations and prenatal outcomes. BMC Med. 2017;15:95. DOI: 10.1186/s12916-017-084.
Gov.UK. Valproate use by women and girls [Internet]. 2018 [cited 2023 Oct 29]. Available from: https://www.gov.uk/guidance/valproate-use-bywomen-and-irls#contents.
Thomas RH. Valproate: Life-saving, life-changing. Clin. Med. 2018;18:1–8. DOI: 10.7861/clinmedicine.18-2-s1.
Huber-Mollema Y, Oort FJ, Lindhout D, Rodenburg R. Well-being of mothers with epilepsy with school-aged children. Epilepsy Behav. 2020;105:106966. DOI: 10.1016/j.yebeh.2020.106966.
Wiggs KK, Rickert ME, Sujan AC, Quinn PD, Larsson H, Lichtenstein P. Antiseizure medication use during pregnancy and risk of ASD and ADHD in children. Neurology 2020;95:3232–40. DOI: 10.1212/WNL.0000000000010993.
Morrell MJ, Hayes FJ, Sluss PM, Adams JM, Bhatt M, Ozkara C, et al. Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine. Ann Neurol. 2008;64:200–11. DOI: 10.1002/ana.21411.
Lamotrigine [Internet]. [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/lamotrigine.
Antiepileptic drugs: Review of safety of use during pregnancy. MHRA UK Public Assessment Report [Internet]. 2021 [cited 2023 Nov 4]. Available from:
Polepally A, Pennell P, Brundage R, Stowe ZN, Newport DJ, Viguera AC, et al. Model-based lamotrigine clearance changes during pregnancy: Clinical implication. Ann Clin Translat Neurol. 2014;1(2):99–106. DOI: 10.1002/acn3.29.
Madley Dowd P, Rast J, Ahlqvist VH, Zhong C, Martin FZ, Davies NM, et al. Trends and patterns of antiseizure medication prescribing during pregnancy between 1995 and 2018 in the United Kingdom: A cohort study. BJOG. 2024 Jan;131(1):15-DOI: 10.1111/1471-0528.17573.
Levetiracetam [Internet]. [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/levetiracetam.
Dupont S, Vercueil L. Epilepsy and pregnancy: What should the neurologists do? Rev Neurol. 2021;177(3):168–79. DOI:10.1016/j.neurol.2021.01.003.
Clobazam [Internet]. [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/clobazam.
Jensen AG, Knudsen SS, Bech BH. Prenatal exposure to benzodiazepines and the development of The offspring – A systematic review. Neurotoxicol Teratol. 2022;91:107078. DOI:10.1016/j.ntt.2022.107078.
Topiramate [Internet]. 2023 [cited 2023 Nov 4]. Available from: https://www.epilepsy.com/tools-resources/seizure-medication-list/topiramate.
Bjork MH, Zoega H, Leinonen MK, Cohen JM, Dreier JW, Furu K, et al. Association of prenatal exposure to antiseizure medication with risk of autism and intellectual disability. JAMA Neurology 2022;79(7): 672–81. DOI: 1001/jamaneurol.2022.1269.
Gooneratne IK, Wimalaratna M, Ranaweera AK, Wimalaratna S. Contraception advice for women with epilepsy. BMJ. 2017;357:j2010. DOI:10.1136/bmj.j2010.
Li Y, Meador KJ. Epilepsy and Pregnancy. CONTINUUM Lifelong Learning in Neurology 2022 Feb 1;28(1):34-54. DOI: 10.1212/CON.0000000000001056.
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