Potential of Mesenchymal Stem Cell Secretome for Regenerative Therapy of Fibrosis Lung Disease
DOI:
https://doi.org/10.55175/cdk.v51i11.1270Keywords:
Pulmonary fibrosis, inflammation, mesenchymal stem cell secretomeAbstract
Mesenchymal stem cells (MSC) associated with anti-inflammatory, immunomodulatory, regenerative, pro-angiogenic, and anti-fibrotic properties offers a novel therapeutic approach for fibrosis lung disease. Such therapeutic effects may be attributed to the MSC-secretome, made from free soluble proteins and extracellular vesicles (EVs). This review summarizes some literature findings related to the efficacy and safety of MSC-derived products in pre-clinical models of lung diseases, demonstrating the biologically active substances contained in the MSC-secretome and its mechanisms involved in tissue regeneration. A perspective view is given on the secretome as a high-quality, safe, and effective
medicinal product.
Downloads
References
Weiss DJ, Casaburi R, Flannery R, LeRoux-Williams M, Tashkin DP. A placebo-controlled, randomized trial of mesenchymal stem cells in COPD. Chest 2013;143(6):1590-8. DOI:10.1378/chest.12-2094.
Barnes PJ. Inflammatory mechanisms in chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016;138(1):16-27. DOI:10.1016/j.jaci.2016.05.011.
Vestbo J, Hurd SS, Agustí AG, Jones PW, Vogelmeier C, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2013;187(4):347-65. DOI:10.1164/rccm.201204-0596PP.
Rabe KF, Watz H. Chronic obstructive pulmonary disease. Lancet 2017;389(10082):1931-40. DOI:10.1016/S0140-6736(17)31222-9.
Fathi E, Farahzadi R, Sheikhzadeh N, et al. Paracrine secretome of adipose tissue-derived mesenchymal stem cells ameliorates pneumonectomy-induced acute lung injury: An in vitro and in vivo study. Stem Cell Res Ther. 2019;10(1):183. DOI: 10.1186/s13287-019-1284-6.
Monsel A, Zhu YG, Gennai S, Hao Q, Hu S, Rouby JJ, et al. Therapeutic effects of human mesenchymal stem cell-derived microvesicles in severe pneumonia in mice. Am J Respir Crit Care Med. 2015;192(3):324-36. DOI: 10.1164/rccm.201410-1765OC.
Liu Y, Lou G, Li A, et al. MSC-secreted exosomes promote lung regeneration in IPF by accelerating alveolar epithelial cell proliferation and inhibiting Wnt/B-catenin signaling. Stem Cell Res Ther. 2020;11(1):19. DOI:10.1186/s13287-020-1540-2.
Ridzuan N, Zakaria N, Widera D, Sheard J, Morimoto M, Kiyokawa H, et al. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles ameliorate airway inflammation in a rat model of chronic obstructive pulmonary disease (COPD). Stem Cell Res Ther. 2021;12:54. DOI: 10.1186/s13287-020-02088-6.
Barnes PJ. Inflammatory mechanisms in chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016;138(1):16-27. DOI:10.1016/j.jaci.2016.05.011.
Zhu H, Xiong Y, Xia Y, Zhang R, Tian D, Wang T, et al. Therapeutic effects of human umbilical cord-derived mesenchymal stem cells in acute lung injury mice. Sci Rep. 2017;7:39889. DOI: 10.1038/srep39889.
Abdullah M, Pawitan JA, Irawan C, Rahyussalim R, Aditianingsih D Liem IK, et al. Effectiveness and safety profile of mesenchymal stem cell secretome as a treatment for severe cases of COVID-19: A randomized controlled trial. F1000Res. 2022;11(1):143-5. DOI: 10.12688/f1000research.75580.2.
Sun YQ, Deng MX, He J, et al. Human mesenchymal stem cells reduce inflammation and alter microbial composition in DSS-induced colitis in mice. Mol Med Rep. 2017;15(2):1315-22. DOI:10.3892/mmr.2016.6086.
Willis GR, Fernandez-Gonzalez A, Anastas J, Vitali SH, Liu X, Ericsson M, et al. Mesenchymal stromal cell exosomes ameliorate experimental bronchopulmonary dysplasia and restore lung function through macrophage immunomodulation. Am J Respir Crit Care Med. 2018;197(1):104-16. DOI: 10.1164/rccm.201705-0925OC.
Bari E, Ferrarotti I, Torre ML, Corsico AG, Perteghella S. Mesenchymal stem/stromal cell secretome for lung regeneration: The long way through "pharmaceuticalization" for the best formulation. J Control Release 2019;309:11-24. DOI: 10.1016/j.jconrel.2019.07.022.
15.Guo H, Su Y, Deng F. Effects of mesenchymal stromal cell-derived extracellular vesicles in lung diseases: Current status and future perspectives. Stem Cell Rev Rep. 2021;17(2):440-58. DOI: 10.1007/s12015-020-10085-8.
16.Zhang B, Yin Y, Lai RC, Lim SK. Immunotherapeutic potential of extracellular vesicles. Front Immunol. 2014;5:518. DOI:10.3389/fimmu.2014.00518.
Khatri M, Richardson LA, Meulia T. Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model. Stem Cell Res Ther. 2018;9(1):17. DOI:10.1186/s13287-017-0750-x.
Willis GR, Fernandez-Gonzalez A, Anastas J, Vitali SH, Liu X, Ericsson M, et al. Mesenchymal stromal cell exosomes ameliorate experimental bronchopulmonary dysplasia and restore lung function through macrophage immunomodulation. Am J Respir Crit Care Med. 2018;197(1):104-16. DOI:10.1164/rccm.201705-0925OC.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Ronald Kartika, Kris Herawan Timotius
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
