Pathogenesis of Melasma
DOI:
https://doi.org/10.55175/cdk.v51i9.1514Keywords:
Antioxidants, UV light, melanogenesis, melasma, free radicals, ROSAbstract
Melasma is a chronic skin pigmentation disorder caused by sunlight exposure. Melasma is a multifactorial disease with various pathways that can induce hyperpigmentation. Exposure to ultraviolet (UV) light as a source of reactive oxygen species (ROS) and free radicals plays a role in the pathogenesis of melasma. Another mechanism is the role of ROS on melanogenesis and melanocyte cells as well as the signaling pathway for melanin synthesis. Concentration of antioxidants as a skin defense against ROS, namely superoxide dismutase (SOD), catalase, and glutathione peroxidase, also influences the occurrence of melasma.
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Esposito ACC, Cassiano DP, da Silva CN, Lima PB, Dias JAF, Hassun K, et al. Update on melasma-part I: Pathogenesis. Dermatol Ther (Heidelb). 2022;12(9):1967-88. DOI: 10.1007/s13555-022-00779-x.
Negbenebor NA, Usatine RP, Heath CR. Melasma. Cutis 2023;111(4):211-2.
Majid I, Aleem S. Melasma: Update on epidemiology, clinical presentation, assessment, and scoring. J Skin Stem Cell 2021;8(4):e120283. DOI: 10.5812/jssc.120283.
Ogbechie-Godec OA, Elbuluk N. Melasma: An up-to-date comprehensive review. Dermatol Ther (Heidelb). 2017;7(3):305-18. DOI: 10.1007/s13555-017-0194-1.
Agrawal MVK, Kumar U, Bhargava S, Mahadik A, Agrawal V. Comparison of oral versus topical tranexamic acid for treatment of melasma. IP Indian J Clin Exp Dermatol. 2023;9(2):84-9.
Handel AC, Miot LD, Miot HA. Melasma: A clinical and epidemiological review. An Bras Dermatol. 2014;89(5):771-82. DOI: 10.1590/abd1806-4841.20143063.
Data morbiditas tahun 2021 divisi dermatologi kosmetik poliklinik KSM dermatologi dan venereologi/RS dr. Cipto Mangunkusumo Jakarta. 2021.
Liu W, Chen Q, Xia Y. New mechanistic insights of melasma. Clin Cosmet Investig Dermatol. 2023;16:429-42. DOI: 10.2147/CCID.S396272.
Maddaleno AS, Camargo J, Mitjans M, Vinardell MP. Melanogenesis and melasma treatment. Cosmetics 2021;8(3):1-11. DOI: 10.3390/cosmetics8030082.
Pfeifer GP. Mechanisms of UV-induced mutations and skin cancer. Genome Instab Dis. 2020;1(3):99-113. DOI: 10.1007/s42764-020-00009-8.
Nakai K, Tsuruta D. What are reactive oxygen species, free radicals, and oxidative stress in skin diseases? Int J Mol Sci. 2021;22(19). DOI: 10.3390/ijms221910799.
Lushchak VI. Free radicals, reactive oxygen species, oxidative stress and its classification. Chem Biol Interact. 2014;224:164-75. DOI: 10.1016/j.cbi.2014.10.016.
Li R, Jia Z, Trush MA. Defining ROS in biology and medicine. React Oxyg Species (Apex). 2016;1(1):9-21. DOI: 10.20455/ros.2016.803.
Ali SS, Ahsan H, Zia MK, Siddiqui T, Khan FH. Understanding oxidants and antioxidants: Classical team with new players. J Food Biochem. 2020;44(3):e13145. DOI: 10.1111/jfbc.13145.
Datta K, Sinha S, Chattopadhyay P. Reactive oxygen species in health and disease. Natl Med J India. 2000;13(6):304-10. DOI: 10.1155/2012/936486.
Brieger K, Schiavone S, Miller FJ, Jr., Krause KH. Reactive oxygen species: From health to disease. Swiss Med Wkly. 2012;142:w13659. DOI: 10.4414/smw.2012.13659.
Chaiprasongsuk A, Onkoksoong T, Pluemsamran T, Limsaengurai S, Panich U. Photoprotection by dietary phenolics against melanogenesis induced by UVA through Nrf2-dependent antioxidant responses. Redox Biology. 2016;8:79-90. DOI: 10.1016/j.redox.2015.12.006.
Katiyar S, Yadav D. Correlation of oxidative stress with melasma: An overview. Curr Pharm Des. 2022;28(3):225-31. DOI: 10.2174/1381612827666211104154928.
Seckin HY, Kalkan G, Bas Y, Akbas A, Onder Y, Ozyurt H, et al. Oxidative stress status in patients with melasma. Cutan Ocul Toxicol. 2014;33(3):212-7. DOI: 10.3109/15569527.2013.834496.
Ertam I, Ozkapu T, Akçay Y, Sozmen E, Unal I. Antioxidant activity in melasma. Turkderm. 2018;52:33-6. DOI: 10.4274/turkderm.19052.
Rahimi H, Mirnezami M, Yazdabadi A, Hajihashemi A. Evaluation of systemic oxidative stress in patients with melasma. J Cosmet Dermatol. 2024 Jan;23(1):284-8. DOI: 10.1111/jocd.15924.
Khaled H, Abdou A, Refay A, Elaziz Hassan R. Evaluation of superoxide dismutase enzyme in patients with melasma: A clinical and immunohistochemical study. Menoufia Med J. 2022;35(3):1057-63. DOI: 10.1111/jocd.15924.
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