Successful Live Birth in Partial Hydatidiform Mole: A Case Report

Case Report

Abstract

Introduction: Partial hydatidiform mole (PHM) is a rare form of gestational trophoblastic disease characterized by abnormal trophoblastic proliferation accompanied by the presence of a fetus. Most cases end in miscarriage, while live births are extremely uncommon. Case: A 22-year-old primigravida diagnosed with PHM, intrauterine growth restriction (IUGR), and oligohydramnios underwent cesarean delivery at 35–37 weeks of gestation, resulting in a live female infant (1,750 g; Apgar scores 8/9). The enlarged placenta (1,180 g) was histopathologically confirmed as PHM. The newborn developed hypoglycemia, thrombocytopenia, and hyperbilirubinemia requiring intensive care, while the mother recovered uneventfully with declining β-hCG levels. Discussion: This case is remarkable as such an occurrence is extremely rare, as most PHM pregnancies end in spontaneous abortion during the first or second trimester due to chromosomal abnormalities and placental insufficiency. Postpartum follow-up revealed a gradual decline in β-hCG levels until they returned to normal, indicating the absence of persistent gestational trophoblastic disease. Conclusion: Pregnancies complicated by PHM require multidisciplinary care and close monitoring, including vigilance during the antenatal period, postpartum evaluation, and appropriate neonatal management to prevent and manage potential complications. Although rare and often associated with poor outcomes, PHM with live birth can achieve favorable results.