Terapi Kondiloma Akuminata dengan Kombinasi Trichloroacetic Acid (TCA) 80% + Krioterapi
DOI:
https://doi.org/10.55175/cdk.v46i6.440Keywords:
Kondiloma akuminata, krioterapi, trichloroacetic acidAbstract
Kondiloma akuminata adalah infeksi yang disebabkan Human Papilloma Virus (HPV) di daerah perineum, genitalia; merupakan penyakit menular seksual paling sering di dunia. Kondiloma akuminata dapat disebabkan oleh berbagai subtipe HPV, terutama HPV 6 dan 11. Dilaporkan satu kasus pasien laki-laki, 43 tahun, dengan keluhan muncul kutil di batang penis, skrotum, dan anus sejak kurang lebih 3 bulan, yang bertambah banyak dan gatal. Pada pemeriksaan daerah genital dan perianal tampak papul dan vegetasi dengan permukaan verukosa, sewarna kulit, multipel. Pasien mendapat terapi kombinasi TCA 80% dengan krioterapi dan simetidin.
Condyloma acuminatum is an infection caused by the Human Papilloma Virus (HPV) in the perineal region, genitalia; It is the most frequent sexually transmitted disease in the world. Kondiloma akuminata can be caused by various HPV subtypes, especially HPV 6 and 11. One case was reported, male patient, 43 years, with warts appearing on the penis, scrotum, and anus since 3 months, which multiplied and itchy. On examination of the genital area and perianal, there are papules and vegetation with verucous surfaces, skin color, multiple. Patients received 80% TCA combination therapy with cryotherapy and cimetidine
Downloads
References
Androphy EJ, Kirnbauer R. Human papilloma virus infections. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, eds. Fitzpatrick's dermatology in general medicine. 2. 8th Ed. New York: McGraw Hill; 2012. p. 2421-33.
Panggabean FR, Hapsari YPS. Pengembangan terakhir pengobatan kutil anogenital. berkala ilmu kesehatan kulit dan kelamin UGM. 2008;20(3):235-42.
Rompalo AM, Quinn TC. Sexually transmitted intestinal syndromes. Condyloma acuminata. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen MS, Watts DH, eds. Sexually transmitted diseases. 4th Ed. New York: McGraw Hill; 2008. p. 1296-7.
Sulaikha KR, Mawardi P. Bedah beku menggunakan teknik semprot terbuka dengan satu dan dua siklus pembekuan-pencairan pada kondiloma akuminata anogenital rekalsitran laki-laki biseksual dengan infeksi HIV. Subdivisi Dermatologi Infeksi Menular Seksual Bagian Ilmu Kesehatan Kulit & Kelamin FK UNS / RSUD Dr. Moewardi; 2016
Patel H, Wagner M, Singhal P, Kothari S. Systematic review of the incidence and prevalence of genital warts. BioMed Central Infect Dis. 2013;13:39.
Murtiastutik D. Penatalaksanaan kondiloma akuminata. In: Barakbah J, Lumintang H, Martodihardjo S, eds. Buku ajar infeksi menular seksual. Surabaya: Fakultas Kedokteran Universitas Airlangga Press; 2008 .p. 170-80
Aminah S, Susila T. Pemilihan terapi pada kutil genital. Mutiara Medika Edisi Khusus. 2007;7(2):134–42
Huang J, Zeng Q, Zuo C, Yang S, Xiang Y, Lu J, et al. The combination of CO2 laser vaporation and photodynamic therapy in treatment of condylomata acuminata. Photodiag Photodyn Ther. 2014;11(2):130–3
Gooderham M. A review of therapeutic options for genital warts. Fam Pract. 2009;5(2)
Juhl ME, Seferovic V, Antonijevic S, Krunic A. Combined treatment of anogenital HPV infection with cryodestruction, podophyllin 25% and post-ablation immunomodulation with sinecatechins 15% ointment - a retrospective analysis. Int J STD AIDS. 2015:1–8
Sherrard J, Riddell L. Comparison of the effectiveness of commonly used clinic-based treatments for external genital warts. Int J STD AIDS. 2007;18(6):365–8
Sharma N, Sharma S, Singhal C. A comparative study of liquid nitrogen cryotherapy as monotherapy versus in combination with podophyllin in the treatment of condyloma acuminata. J Clin Diagn Res. 2017;11(3):1-5
Sheet CDCF. FACT incidence, prevalence, and cost of sexually transmitted infections in the United States. Nearly 20 Million New Infections Occur Each Year – Half among the Nation’s Youth. 2013;40:1–4
Fitzpatrick TB, Wolff K, Allen R. Color atlas & synopsis of clinical dermatology. 6th Ed. New York: McGraw-Hill Inc; 2009 .pp. 861-9.
Workowski KA, Bolan GA. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 22015;64:1-137.
Mulhall BP. Epidemiological Interactions between HIV-1 and other STI: A complex, continuing narrative. In: Gupta S, Kumar B, eds. Sexually transmitted infections. 2nd Ed. Delhi: Elsevier; 2012. p. 74-87.
Dindo D, Nocito A, Schettle M, Clavien PA, Hahnloser D. What should we do about anal condyloma and anal intraepithelial neoplasia? Results of a survey. Color Dis. 2011;13(7):796–801
Piggott C, Friedlander SF. Molluscum contagiosum. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, eds. Fitzpatrick's dermatology in general medicine. 2. 8th Ed. New York: McGraw Hill; 2012. pp. 2417-20
Weedon D. Molluscum contagiosum. Weedon's skin pathology. 3rd Ed. London: Churchil Livingstone Elsevier; 2010. pp. 609-10
D’Ambrogio A, Yerly S, Sahli R, Bouzourene H, Demartines N, Cotton M, et al. Human papilloma virus type and recurrence rate after surgical clearance of anal condylomata acuminata. Sex Transm Dis. 2009;36(9):536–40
Pezeshkpoor F, Banihashemi M, Yazdanpanah MJ, Yousefzadeh H, Sharghi M, Hoseinzadeh H. Comparative study of topical 80% trichloroacetic acid with 35% trichloroacetic acid in the treatment of the common wart. J Drugs Dermatol 2012;11(11):66–9
Abdullah AN, Walzman M, Wade A. Treatment of external genital warts comparing cryotherapy (liquid nitrogen) and trichloroacetic acid. Sexually Transmitted Dis. 1993;20:344–5
Scheinfeld N, Lehman DS. An evidence-based review of medical and surgical treatments of genital warts. Dermatol Online J. 2006;12(3):5
Vinod K Sharma SK. Guidelines for cryotherapy. Indian J Dermatol Venereol Leprol. 2009;75(8):90–100
Kuflik EG. Cryosurgery. In: Roenigk RK, Ratz JL, Henry H Roenigk J, eds. Roenigk's dermatologic surgery current techniques in procedural dermatology. 3rd Ed. New York: Informa; 2007. pp. 173-86
Pasquali P. Cryosurgical techniques. In: Pasquali P, ed. Cryosurgery a practical manual. Heidelberg: Springer; 2015. pp.65-76
Uyar B, Sacar H. Comparison of cryotherapy session intervals in the treatment of external genital warts. Dermatologica Sin. 2014;32(3):154–6
Gilson R, Ross J, Maw R, Rowen D, Lacey C, Gilson R, et al. Placebo-controlled study of cryotherapy versus cryotherapy and podophyllotoxin cream as treatment for external anogenital warts . 2011;85(7).
Sinha S, Relhan V, Garg VK. Immunomodulators in warts: Unexplored or ineffective? Indian J Dermatol. 2015;60(2):118-29
Culton DA, Morrell DS, Burkhart CN. The management of condyloma acuminata in the pediatric population. Pediat Ann. 2009;38(7):368-72
Kirnbauer R, Lenz P, Okun M. Human papilloma virus. In: Bolognia JL, Jorizzo JL, Rapini RP, eds. Dermatology. 2nd ed. New York: Mosby Elsevier; 2008 .p. 1180-97
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 https://creativecommons.org/licenses/by-nc/4.0/
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.