Penggunaan Hydroxychloroquine dalam Tatalaksana Covid-19
DOI:
https://doi.org/10.55175/cdk.v47i10.552Keywords:
COVID-19, hydroxychloroquineAbstract
Penyakit coronavirus 2019 (Covid-19) telah menyebar dengan cepat ke seluruh dunia. Saat ini berbagai obat telah diteliti dalam upaya mengobati dan mencegah penularan virus tersebut, salah satunya adalah hydroxychloroquine yang selama ini dikenal sebagai obat antimalaria dan obat penyakit autoimun seperti lupus eritemasosus sistemik. Selain efek imunomodulasi, studi in vitro menunjukkan bahwa hydroxychloroquine juga memiliki efek antivirus, namun studi pada pasien Covid-19 hasilnya bervariasi dalam hal perbaikan outcome. Saat ini pada kondisi pandemi, hydroxychloroquine secara darurat bisa digunakan terbatas dalam pengawasan ketat oleh dokter untuk pengobatan pasien Covid-19 dewasa dan remaja yang memiliki berat badan 50 kg atau lebih dan dirawat di rumah sakit.
The 2019 coronavirus disease (Covid-19) has spread rapidly throughout the world. Various drugs have been studied for treating and preventing virus transmission, including hydroxychloroquine, known as antimalarial and an autoimmune disease drug such as systemic lupus erythematosus. In addition to an immunomodulating effect, in vitro studies have shown that hydroxychloroquine also has antiviral effects, but studies on Covid-19 patients have shown mixed results. Currently, in pandemic conditions, hydroxychloroquine can be limitedly used for emergency under close medical supervision for treating adults and adolescents weighed 50 kg or more with Covid-19 in a hospital setting.
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