Efektivitas Citicoline sebagai Agen Neuroprotektif dalam Tata Laksana Traumatic Brain Injury
DOI:
https://doi.org/10.55175/cdk.v50i12.1015Kata Kunci:
Citicoline, Glasgow Coma Scale, traumatic brain injuryAbstrak
Latar belakang: Traumatic brain injury (TBI) adalah salah satu kondisi yang diakibatkan trauma fisik pada kepala yang dapat menyebabkan kerusakan struktural otak serta mengganggu fungsi kognitif, motorik, dan emosional. Citicoline adalah senyawa alami yang berperan penting dalam metabolisme fosfolipid dan sintesis neurotransmiter di otak. Penelitian evidence-based case report (EBCR) ini bertujuan untuk memberikan bukti ilmiah mengenai manfaat potensial citicoline dalam meningkatkan hasil klinis pasien TBI. Metode: Penelusuran literatur menggunakan format PICO. Rumusan pertanyaan klinis disusun berdasarkan kasus. Pencarian artikel pada 6–7 Maret 2023 menggunakan software Publish or Perish (PoP) dengan target pencarian artikel 10 tahun terakhir (2013-2023) pada database Scopus, Pubmed, Google Scholar, dan pencarian manual pada database Cochrane, menggunakan kata kunci 'traumatic brain injury' AND 'therapy' AND 'citicoline' AND 'neuroprotective' AND 'treatment' AND 'outcome' beserta sinonim dan istilah terkait. Hasil: Didapat empat studi, dengan level of evidence 1a yang merupakan hasil meta-analisis atau tinjauan sistematik dari berbagai uji klinik acak dengan kontrol (randomized controlled trials), yang kemudian ditinjau secara kritis. Dua studi melaporkan tidak ada signifikansi penilaian klinis dan Glasgow Coma Scale (GCS); dua studi lain menunjukkan hasil signifikan pada tingkat kemandirian. Simpulan: Studi ini menunjukkan citicoline bermanfaat pada kemandirian penderita TBI, tetapi tidak menghasilkan perbedaan signifikan pada penilaian Glasgow Coma Scale.
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