Tata Laksana Terkini Dermatitis Atopik Sedang dan Berat: Dari Patogenesis hingga Terobosan Tata Laksana.
DOI:
https://doi.org/10.55175/cdk.v51i7.1096Kata Kunci:
Dermatitis atopik, antibodi monoklonal, terapiAbstrak
Dermatitis atopik (DA), kondisi yang ditandai dengan lesi eksim berulang dan pruritus, merupakan kontributor utama beban kecacatan global. Praktik penatalaksanaan yang umum mencakup edukasi pasien dan emolien topikal serta agen antiinflamasi corticosteroid sistemik. Antibodi monoklonal merupakan suatu pendekatan tata laksana baru dan mampu menarget sitokin spesifik. Penelitian ini bertujuan menyoroti obat sistemik baru untuk target spesifik seperti antibodi monoklonal. Tinjauan literatur komprehensif menggunakan database EMBASE, EBSCOhost, PubMed, Scopus, dan Wiley Online Library, dengan kata kunci: “antibodi monoklonal” DAN “terapi” DAN “dermatitis atopik”. Penelitian relevan berisi pembaruan pengelolaan DA dan penggunaan antibodi monoklonal disertakan dalam tinjauan ini. Antibodi monoklonal yang telah dikembangkan hingga saat ini menawarkan penatalaksanaan DA sedang hingga berat yang lebih baik. Namun, penerapannya masih menghadapi berbagai tantangan seperti efek samping dan risiko infeksi. Heterogenitas dan sifat kekambuhan juga menambah kompleksitas dan profil risiko pengelolaan DA.
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