Lupus Eritematosus Sistemik (SLE) dengan Krisis Hipertensi pada Kehamilan
Laporan Kasus
DOI:
https://doi.org/10.55175/cdk.v52i4.1144Kata Kunci:
Penyakit autoimun, komplikasi kehamilan, lupus eritematosus sistemikAbstrak
Pendahuluan: Meskipun belum ada data spesifik prevalensi SLE di Indonesia, penyakit ini lebih umum pada wanita usia subur. Kasus: Wanita hamil 24 tahun dengan riwayat SLE mengeluh sesak napas, kaki bengkak, dan kelelahan yang memburuk sejak bulan kedua kehamilannya. Saat masuk rumah sakit didiagnosis krisis hipertensi berat, SLE aktif (ginjal, sendi, kulit), gagal jantung kongestif, dan anemia. Perawatan intensif dilakukan di ICU. Diskusi: SLE merupakan penyakit autoimun yang memengaruhi berbagai organ. Manajemen yang hati-hati dan pemantauan diperlukan selama kehamilan untuk kesejahteraan ibu dan janin. Simpulan: Wanita hamil dengan SLE berisiko komplikasi kehamilan. Penanganan komprehensif diperlukan untuk hasil yang baik.
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Referensi
Li J, Leng X, Li Z, Ye Z, Li C, Li X, et al. Chinese SLE treatment and research group registry: III. association of autoantibodies with clinical manifestations in Chinese patients with systemic lupus erythematosus. J Immunol Res. 2014;2014(1):1–8. DOI: 10.1155/2014/809389.
van Hagen PM, Dik WA, van Bilsen K. Lupus erythematosus. 2nd Ed. Encyclopedia of gastroenterology, second edition. Elsevier Inc.; 2019. p.472–76.
Tian J, Zhang D, Yao X, Huang Y, Lu Q. Global epidemiology of systemic lupus erythematosus: A comprehensive systematic analysis and modelling study. Ann Rheum Dis. 2023;82(3):351–6. DOI: 10.1136/ard-2022-223035.
Sumariyono S, Kalim H, Setyohadi B, Hidayat Ru, Najirman N, Hamijoyo L, et al. Rekomendasi Perhimpunan Reumatologi Indonesia: Diagnosis dan pengelolaan lupus eritematosus sistemik. 2019. Jakarta: Perhimpunan Reumatologi Indonesia; 2019.
Justiz Vaillant AA, Goyal A, Varacallo M. Systemic lupus erythematosus. Treasure Island (FL); 2023.
Fischer-Betz R, Specker C. Pregnancy in systemic lupus erythematosus and antiphospholipid syndrome. Best Pract Res Clin Rheumatol. 2017;31(3):397–414. DOI: 10.1016/j.berh.2017.09.011.
Andreoli L, Bertsias GK, Agmon-Levin N, Brown S, Cervera R, Costedoat-Chalumeau N, et al. EULAR recommendations for women’s health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. Ann Rheum Dis. 2017;76(3):476–85. DOI: 10.1136/annrheumdis-2016-209770.
Zdrojewski Z. Systemic lupus erythematosus and antiphospholipid syndrome - diagnostic and therapeutic problems. Wiad Lek. 2018;71(1):40–6. PMID: 29558350.
Choe JY, Park SH, Kim JY, Jung HY, Kim SK. A case of systemic lupus erythematosus presenting as malignant hypertension with hypertensive retinopathy. Korean J Intern Med. 2010;25(3):341–4. DOI: 10.3904/kjim.2010.25.3.341.
Clowse MEB, Eudy AM, Balevic S, Sanders-Schmidler G, Kosinski A, Fischer-Betz R, et al. Hydroxychloroquine in the pregnancies of women with lupus: a meta-analysis of individual participant data. Lupus Sci Med. 2022;9(1):e000651. DOI: 10.1136/lupus-2021-000651.
Muhammad O, Jindal H, Sharath M, Khan AM, Choi S. Systemic lupus erythematosus with multi-organ involvement in a young female: Lymphadenopathy, lupus cerebritis, lupus nephritis, and cardiac manifestations. Cureus 2021;13(6):e15517. DOI: 10.7759/cureus.15517.
Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, et al. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019;78(9):1151–9. DOI: 10.1136/annrheumdis-2018-214819.
Pisetsky DS, Lipsky PE. Role of antinuclear antibody determinations in classification criteria for systemic lupus erythematosus: Comment on the article by Leuchten et al. Arthritis Care Res (Hoboken). 2019;71(5):696. DOI: 10.1002/acr23559.
Drosos GC, Vedder D, Houben E, Boekel L, Atzeni F, Badreh S, et al. EULAR recommendations for cardiovascular risk management in rheumatic and musculoskeletal diseases, including systemic lupus erythematosus and antiphospholipid syndrome. Ann Rheum Dis. 2022;81(6):768–79. DOI: 10.1136/annrheumdis-2021-221733.
Musa R, Brent LH, Qurie A. Lupus nephritis. National Library of Medicine [Internet]. 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499817/.
Tamirou F, Houssiau FA. Management of lupus nephritis. J Clin Med. 2021;10(4):1–7. DOI: 10.3390/jcm10040670.
Baalbaki S, Szychowski JM, Tang Y, Wetta L, Subramaniam A. Systemic lupus erythematosus: Perinatal outcomes in patients treated with and without hydroxychloroquine. Ochsner J. 2020;20(4):362 LP – 367. DOI: 10.31486/toj.20.0013.
Duan J, Ma D, Wen X, Guo Q, Gao J, Zhang G, et al. Hydroxychloroquine prophylaxis for preeclampsia, hypertension and prematurity in pregnant patients with systemic lupus erythematosus: A meta-analysis. Lupus 2021;30(7):1163–74. DOI: 10.1177/09612033211007199.
Huang PZ, Du PY, Han C, Xia J, Wang C, Li J, et al. Pre-eclampsia with new-onset systemic lupus erythematosus during pregnancy: A case report. World J Clin Cases. 2019;7(22):3800–6. DOI: 10.12998/wjcc.v7.i22.3800.
Miyamoto T, Hoshino T, Hayashi N, Oyama R, Okunomiya A, Kitamura S, et al. Preeclampsia as a manifestation of new-onset systemic lupus erythematosus during pregnancy: A case-based literature review. AJP Rep. 2016;6(1):1–7. DOI: 10.1055/s-0035-1566245.
Donohue S, Gomez S, Singh T, Garg S. Triphasic: Preeclampsia, systemic lupus erythematosus, and severe neutropenia with use of granulocyte colony stimulating factor in the partum and postpartum period. Arthritis Care Res (Hoboken). 2023;75(10):2036–43. DOI: 10.1002/acr.25138.
Sammaritano LR. Management of systemic lupus erythematosus during pregnancy. Annu Rev Med. 2017;68(1):271–85. DOI: 10.1146/annurev-med-042915-102658.
Saleh M, Sjowall C, Strevens H, Jönsen A, Bengtsson AA, Compagno M. Adverse pregnancy outcomes after multi-professional follow-up of women with systemic lupus erythematosus: An observational study from a single centre in Sweden. J Clin Med. 2020;9(8):1–7. DOI: 10.3390/jcm9082598.
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