Thromboangitis Obliterans (TAO): Diagnosis dan Tatalaksana

Penulis

  • Silvia Apriliana Balai Penelitian dan Pengembangan Kesehatan Banjarnegara, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan Republik Indonesia

DOI:

https://doi.org/10.55175/cdk.v48i12.169

Kata Kunci:

TAO, thromboangitis obliterans

Abstrak

Thromboangitis obliterans (TAO) atau Buerger’s disease merupakan penyakit inflamasi non-aterosklerotik yang ditandai dengan oklusi segmental pada pembuluh darah arteri kecil dan sedang serta pembuluh darah vena baik ekstremitas atas maupun bawah. Etiologi TAO masih belum diketahui, tetapi berkaitan erat dengan kebiasaan merokok. Diagnosis berdasarkan riwayat dan gejala klinis, pemeriksaan fisik, dan pemeriksaan penunjang. Penghentian penggunaan tembakau menjadi terapi definitif dan efektif. Terapi lain di antaranya dengan obat-obatan, bedah revaskularisasi, terapi endovaskular, penggunaan sel induk/stem cell, simpatektomi, dan stimulasi saraf tulang belakang.

Thromboangitis obliterans (TAO) or Buerger’s disease is a non-atherosclerotic inflammatory disease characterized by segmental occlusion; commonly affects small and medium-sized arteries and veins in upper and lower extremities. The etiology of TAO is still unknown, but closely related to smoking. Diagnosis is based on clinical features with a compatible history, physical examination, laboratory test, and and imaging. There is no standard therapy for this disease. Tobacco use cessation is the definitive and effective therapy. Other therapies include drugs, revascularization surgery, endovascular therapy, use of stem cells, sympathectomy, and spinal cord stimulation.

Unduhan

Data unduhan belum tersedia.

Referensi

Jamadi JG, Wirka IM, Sariffudin. Thromboangiitis obliterans (Buerger’s disease). J Med Prof. 2019;1(1):32-38.

Le Joncour A, Soudet S, Dupont A, Espitia O, Koskas F, Cluzel P, et al. Long-term outcome and prognostic factors of complications in thromboangiitis obliterans (Buerger’s disease): A multicenter study of 224 patients. J Am Heart Assoc. 2018;7(23):1-9. doi:10.1161/JAHA.118.010677

Rivera-Chavarría IJ, Brenes-Gutiérrez JD. Thromboangiitis obliterans (Buerger’s disease). Ann Med Surg. 2016;7(March):79-82. doi:10.1016/j.amsu.2016.03.028

Vijayakumar A, Tiwari R, Kumar Prabhuswamy V. Thromboangiitis obliterans (Buerger’s disease) - Current practices. Int J Inflam. 2013;2013. doi:10.1155/2013/156905

Sun X Lei, Law BYK, de Seabra Rodrigues Dias IR, Mok SWF, He Y Zheng, Wong VKW. Pathogenesis of thromboangiitis obliterans: Gene polymorphism and immunoregulation of human vascular endothelial cells. Atherosclerosis 2017;265:258-65. doi:10.1016/j.atherosclerosis.2017.08.009

Oktaria D, Samosir RK. Kriteria diagnosis dan tatalaksana pada Buerger’s disease dwita. Majority 2017;6:126-31.

Martin-Rufino JD, Lozano FS, Redondo AM, Villaron EM, Rueda R, Fernandesz-Samos R, et al. Sequential intravenous allogeneic mesenchymal stromal cells as a potential treatment for thromboangiitis obliterans (Buerger’s disease). Stem Cell Res Ther. 2018;9(1):1-6. doi:10.1186/s13287-018-0901-6

Cacione DG, do Carmo Novaes F, Moreno DH. Stem cell therapy for treatment of thromboangiitis obliterans (Buerger’s disease). Cochrane Database Syst Rev. 2018;2018(10). doi:10.1002/14651858.CD012794.pub2

Piazza G, Creager MA. Thromboangiitis obliterans. Circulation. 2010;121(16):1858-61. doi:10.1161/CIRCULATIONAHA.110.942383

Karakoyun R, Köksoy C, Şener Z, Gündüz U, Karakaş B, Karakoyun M. Comparison of quality of life in patients with peripheral arterial disease caused by atherosclerosis obliterans or Buerger’s disease. Cardiovasc J Afr. 2014;25(3):124-9. doi:10.5830/CVJA-2014-017

Hernawan H. Laporan kasus: Thromboangitis obliterans dengan komorbid DVT. Syifa’MEDIKA J Kedokt dan Kesehat. 2016;6(2):66-73.

Lee CY, Choi K, Kwon H, Ko GY, Han Y, Kwon TW, et al. Outcomes of endovascular treatment versus bypass surgery for critical limb ischemia in patients with thromboangiitis obliterans. PLoS One. 2018;13(10):1-10. doi:10.1371/journal.pone.0205305

De Haro J, Acin F, Bleda S, Varela C, Esparza L. Treatment of thromboangiitis obliterans (Buerger’s disease) with bosentan. BMC Cardiovasc Disord. 2012;12.doi:10.1186/1471-2261-12-5

Ryu SW, Jeon HJ, Cho SS, Choi RM, Yoon JS, Ko HS, et al. Treatment of digit ulcers in a patient with Buerger’s disease by using cervical spinal cord stimulation -a case report. Korean J Anesthesiol. 2013;65(2):167-71. doi:10.4097/kjae.2013.65.2.167

Diterbitkan

2021-12-01

Cara Mengutip

Silvia Apriliana. (2021). Thromboangitis Obliterans (TAO): Diagnosis dan Tatalaksana. Cermin Dunia Kedokteran, 48(12), 713–717. https://doi.org/10.55175/cdk.v48i12.169

Terbitan

Bagian

Articles