Pengaruh Suplemen Omega-3 terhadap Marker Peradangan pada Pasien Kanker Kolorektal: Laporan Kasus Berbasis Bukti
Laporan Kasus Berbasis Bukti
DOI:
https://doi.org/10.55175/cdk.v53i02.2038Kata Kunci:
Kanker kolorektal, CRP, imunonutrisi, inflamasi, omega-3Abstrak
Pendahuluan: Asam lemak tak jenuh ganda omega-3 (polyunsaturated fatty acids/PUFAs), khususnya EPA dan DHA, memiliki efek imunomodulator dan antiinflamasi yang berpotensi menurunkan penanda inflamasi seperti interleukin-6 (IL-6) dan C-reactive protein (CRP) pasien kanker kolorektal (CRC). Metode: Pencarian literatur dilakukan di PubMed, Cochrane Library, dan Google Scholar, dari Mei hingga Juni 2025. Studi yang disertakan merupakan meta-analisis atau uji terkontrol acak (RCT) yang mengevaluasi suplementasi omega-3 pada
pasien CRC dewasa, dengan fokus pada penanda inflamasi sebagai luaran utama. Penilaian kritis dan tingkat bukti berdasarkan Oxford Centre for Evidence-Based Medicine. Hasil: Tiga meta-analisis ditelaah. Suplementasi omega-3 diberikan secara oral (660 mg–4,8 g/hari) atau parenteral (0,1–0,2 g/kg/hari) selama 5 hingga 84 hari. Kadar IL-6 dan TNF-α menurun signifikan dalam sebagian besar studi.
CRP menunjukkan perbaikan moderat dan tidak konsisten, dengan albumin sedikit meningkat. Heterogenitas tinggi dalam dosis, waktu, dan rute pemberian membatasi kekuatan interpretasi. Simpulan: Suplementasi omega-3 tampak menurunkan inflamasi sistemik pada pasien
CRC, terutama melalui penekanan IL-6. Meskipun efek terhadap CRP tidak konsisten dan peningkatan albumin tergolong ringan, temuan ini menunjukkan potensi manfaat terhadap status inflamasi dan nutrisi. Diperlukan RCT berkualitas tinggi dengan protokol yang distandarisasi
untuk mengonfirmasi manfaat klinis dan strategi dosis optimal.
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Referensi
Morgan E, Arnold M, Gini A, Lorenzoni V, Cabasag CJ, Laversanne M, et al. Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut. 2023;72(2):338–44. doi:10.1136/gutjnl-2022-327736.
International Agency for Research on Cancer. Indonesia - Fact sheet [Internet]. GLOBOCAN 2022. 2024 [cited 2025 Jun 1]. Available from: https://gco.iarc.who.int/today.
Guida AM, Franceschilli M, Leonetti G, Bellato V, Pirozzi BM, Fiorani C, et al. Pathophysiology of metabolic changes and malnutrition in colorectal cancer’s patients. AME Med J. 2025;10:13. doi:10.21037/amj-23-154.
Kapała A, Rozycka K, Grochowska E, Gazi A, Motacka E, Folwarski M. Cancer, malnutrition and inflammatory biomarkers: why do some cancer patients lose more weight than others? Contemp Oncol (Pozn). 2025;29(1):45–54. doi:10.5114/wo.2025.147939.
Silva JAP, Trindade EBSM, Fabre MES, Menegotto VM, Gevaerd S, Buss ZS, et al. Fish oil supplement alters markers of inflammatory and nutritional status in colorectal cancer patients. Nutr Cancer. 2012;64(2):267–73. doi: 10.1080/01635581.2012.643133.
Tojjari A, Choucair K, Sadeghipour A, Saeed A, Saeed A. Anti-inflammatory and immune properties of polyunsaturated fatty acids (PUFAs) and their impact on colorectal cancer (CRC) prevention and treatment. Cancers (Basel). 2023;15(10):2599. PMID: 37686570.
Oxford Centre for Evidence-Based Medicine. Oxford Centre for Evidence-Based Medicine – Levels of evidence (March 2009) [Internet]. Oxford: University of Oxford; 2009 [cited 2025 Jun 14]. Available from: https://www.cebm.ox.ac.uk/resources/levels-of-evidence/oxford-centre-for-evidence-based-medicine-levels-of-evidence-march-2009.
Liu H, Chen J, Shao W, Yan S, Ding S. Efficacy and safety of omega-3 polyunsaturated fatty acids in adjuvant treatments for colorectal cancer: a meta-analysis of randomized controlled trials. Front Pharmacol. 2023;14:1137474. doi: 10.3389/fphar.2023.1004465.
Li L, Wang D, He N, Dai S, Tu L, Fu R, et al. Effects of polyunsaturated fatty acids on colorectal cancer patients: a meta-analysis of randomized controlled trials. Nutr Cancer. 2023;75(5):627–39. doi: 10.1080/01635581.2022.2145319.
Wibowo AA, Willyanto NA. The efficacy of omega-3 fatty acids (O3FAs) as a complementary in colorectal cancer patients: a systematic review and meta-analysis. Clin Nutr ESPEN. 2024;61:322–32. doi: 10.1016/j.clnesp.2024.04.002.
Lee SY, Park HM, Kim CH, Kim HR. Role of preoperative immunonutrition in patients with colorectal cancer: a narrative review. Ann Clin Nutr Metab. 2023;15(2):46–50. doi:10.15747/ACNM.2023.15.2.46.
Piekarska B, Prusisz M, Włodarczyk M, Włodarczyk J, Porc M, Bilinska I, et al. The impact of preoperative and postoperative nutritional interventions on treatment outcomes and quality of life in colorectal cancer patients: a comprehensive review. Medicina (Kaunas). 2024;60(4):667. doi: 10.3390/medicina60101587.
Volpato M, Hull MA. Omega-3 polyunsaturated fatty acids as adjuvant therapy of colorectal cancer. Cancer Metastasis Rev. 2018;37(2–3):545–55. doi:10.1007/s10555-018-9744-y.
Xie H, Chang Y. Omega-3 polyunsaturated fatty acids in the prevention of postoperative complications in colorectal cancer: a meta-analysis. Onco Targets Ther. 2016;9:7435–43. doi:10.2147/OTT.S113575.
Braga M, Gianotti L, Vignali A, Di Carlo V. Preoperative oral arginine and n-3 fatty acid supplementation improves the immunometabolic host response and outcome after colorectal resection for cancer. Surgery 2002;132(5):805–14. doi: 10.1067/msy.2002.128350.
Mocellin MC, Pastore e Silva JA, Camargo CDQ, Fabre MES, Gevaerd S, Naliwaiko K, et al. Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. Lipids. 2013;48(9):879–88. doi:10.1007/s11745-013-3816-0.
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