Terapi Berbasis Sel: Perkembangan Terkini
DOI:
https://doi.org/10.55175/cdk.v49i3.207Kata Kunci:
Imunoterapi, sistem imunAbstrak
Terapi berbasis sel mulai mendapat perhatian ketika James P. Allison dan Tasuku Honjo mendapat hadiah Nobel bidang fisiologi/kedokteran pada tahun 2018 atas penemuan mekanisme inhibisi regulasi sel T dalam sistem imun, yang sangat berguna untuk memajukan modalitas imunoterapi. Terapi berbasis sel sejauh ini menggunakan dua jenis sel, yaitu sel imun dan sel punca. Terapi berbasis sel potensial sebagai terapi medis di masa depan, meskipun kini masih dalam tahap penelitian. Artikel ini bertujuan memberikan pengantar seputar terapi berbasis sel dan perkembangan terkininya.
Cell-based therapies start to gain attention when Nobel prize in physiology/medicine was awarded to James P. Allison and Tasuku Honjo in 2018 for their discovery in immune system’s T cell inhibition mechanism which is very valuable in immunotherapy. To date, cell-based therapies consist of two types of cells: immune cells and stem cells. Cell-based therapies are deemed future therapy in medicine, although their use are currently still in the research phase. This review is an overview and recent updates regarding cell-based therapies.
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Referensi
Press release: The Nobel Prize in physiology or medicine 2018 [Internet]. 2018 [cited 2021 Jan 10]. Available from: https://www.nobelprize.org/prizes/medicine/2018/press-release/
UI resmikan pusat produksi sel punca dan produk metabolit nasional [Internet]. 2019 Dec 18 [cited 2021 Apr 1]. Available from: https://www.ui.ac.id/ui-resmikanpusat-produksi-sel-punca-dan-produk-metabolit-nasional/
Anna LK, editor. Sel punca tak obati semua penyakit. Kompas [Internet]. 2015 Oct 29 [cited 2021 Jan 10]. Available from:https://health.kompas.com/read/2015/10/29/141500623/Sel.Punca.Tak.Obati.Semua.Penyakit?page=all
American Society of Gene + Cell Therapy. Gene and cell therapy FAQ’s [Internet]. [cited 2021 Jan 10]. Available from: https://www.asgct.org/education/moreresources/gene-and-cell-therapy-faqs
Elbuluk A, Einhorn TA, Iorio R. A comprehensive review of stem-cell therapy. JBJS Rev. 2017;5(8):15.
Zakrzewski W, Dobrzyński M, Szymonowicz, Rybak Z. Stem cells: Past, present, and future. Stem Cell Res Ther. 2019;10(1):68.
Mummery C, Van de Stolpe A, Roelen BAJ, Clevers H. Stem cell: Scientific facts and fiction. 2nd ed. UK: Elsevier; 2014.
Feins S, Kong W, Williams EF, Milone MC, Fraietta JA. An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer. Am J Hematol.2019;94(1):3-9.
Mohanty R, Chowdhury CR, Arega S, Sen P, Ganguly P, Ganguly N. CAR T cell therapy: A new era for cancer treatment (Review). Oncol Rep. 2019;42(6):2183-95.
Androulla MN, Lefkothea PC. CAR T-cell therapy: A new era in cancer immunotherapy. Curr Pharm Biotechnol. 2018;19(1):5-18.
Anguela XM, High KA. Entering the modern era of gene therapy. Annu Rev Med. 2019;70:273-88.
Food and Drug Administration. What is gene therapy? How does it work? [Internet]. 2017 [cited 2021 Jan 10]. Available from: https://www.fda.gov/consumers/consumer-updates/what-gene-therapy-how-does-it-work
Patil SR, Al-Zoubi IA, Raghuram PH, Misra N, Yadav N, Alam MK. Gene therapy: A comprehensive review. Int Med J. 2018;25(6):361-4.
Amin S, Chen S. Pluripotent stem cells and their therapeutic applications. In: Templeton NS, editor. Gene and cell therapy – Therapeutic mechanisms and strategies. 4th ed. USA: Taylor & Francis Group; 2015. p.743-56.
Food and Drug Administration. Approved cellular and gene therapy products [Internet]. 2021 [cited 2021 Jan 10]. Available from: https://www.fda.gov/vaccinesblood-biologics/cellular-gene-therapy-products/approved-cellular-and-gene-therapy-products
Food and Drug Administration. Consumer alert on regenerative medicine products including stem cells and exosomes [Internet]. 2020 [cited 2021 Jan 10]. Available from: https://www.fda.gov/vaccines-blood-biologics/consumers-biologics/consumer-alert-regenerative-medicine-products-including-stem-cells-andexosomes
Somasundaram I, Anandan K, Marappagounder D. Promises of stem cell research and therapeutics. In: Somasundaram I, editor. Stem cell therapy for organ failure. India: Springer; 2014. p.3-13.
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