Perawatan Mulut untuk Pencegahan Mukositis Oral pada Penderita Kanker Anak yang Mendapat Kemoterapi
DOI:
https://doi.org/10.55175/cdk.v46i6.438Kata Kunci:
Anak, kemoterapu, mukositis oral, perawatan mulutAbstrak
Mukositis oral merupakan peradangan mukosa rongga mulut yang sering ditemukan pada pasien yang mendapat kemoterapi antikanker. Angka kejadian mukositis oral pada populasi anak dan remaja sebesar 40-50%. Mukositis oral dapat berdampak negatif antara lain penurunan kualitas hidup, pengurangan dosis terapi antikanker, dan peningkatan biaya perawatan. Perawatan mulut meliputi evaluasi berkala kondisi mulut, edukasi pasien dan/atau keluarga, penyikatan gigi, flossing, dan berkumur sangat disarankan untuk mengurangi angka kejadian mukositis oral.
Oral mucositis is an inflammation of the oral cavity mucosa; it is the most common complication of cancer chemotherapy. The incidence rate of oral mucositis in pediatric and adolescent population is 40-50%. Oral mucositis can cause negative impacts on quality of life, dose reduction of anticancer treatment, and increase inhealth care cost. Basic principles of oral health care consisting of periodic oral health evaluation, educating patient and/or parents, tooth brushing, flossing, and mouth rinsing are recommended to reduce the incidence of oral mucositis.
Unduhan
Referensi
McLean TW, Wofford MM. Prinsip terapi kanker. In: Marcdante KJ, Kliegman RM, Jenson HB, Behrman RE, editors. Nelson: Ilmu kesehatan anak esensial. 6th Ed.Singapore: Elsevier; 2014. p. 634-9.
Lalla RV, Sonis ST, Peterson DE. Management of oral mucositis in patient with cancer. Dent Clin North Am. 2008;52:61-viii.
D Hondt L, Lonchay C, Andre M, Canon J. Oral mucositis induced by anticancer treatments: Physiopathology and treatments. Ther Clin Risk Manage. 2006;2:159.
Bensinger W, Schubert M, Ang KK, Brizel D, Brown E, Eilers JG, et al. NCCN task force report: Prevention and management of mucositis in cancer care. J Natl Compr Canc Netw. 2008;6(S1):1-24.
Bowen JM, Elad S, Hutchins RD, Lalla RV. Mucositis study group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO. Methodology for the MASCC/ISOO mucositis clinical practice guidelines update). Support Care Cancer. 2013;21:303-8.
Mulatsih S, Sri Astuti S, Purwantika Y, Christine J. Kejadian dan tatalaksana mukositis pada pasien keganasan di RSUP Dr. Sardjito, Yogyakarta. Sari Pediatri. 2008;10:230-5.
Cheng KK, Lee V, Li CH, Thompson DR, Yuen HL, Epstein JB. Incidence and risk factors of oral mucositis in paediatric and adolescent patients undergoing chemotherapy. Oral Oncol. 2011;47:153-62.
El-Housseiny A, Saleh S, El-Masry A, Allam A. Assessment of oral complications in children receiving chemotherapy. J Clin Pediatr Dent. 2007;31:267-73.
Al-Ansari S, Zecha JA, Barasch A, de Lange J, Rozema FR, Raber-Durlacher JE. Oral mucositis induced by anticancer therapies. Curr Oral Health Rep. 2015;2(4):202-11.
Naidu MU, Ramana GV, Rani PU, Suman A, Roy P. Chemotherapy induced and/or radiation therapy induced oral mucositis complicating the treatment of cancer. Neoplasia. 2004;6:423-31.
Pico JL, Avila-Garavito A, Naccache P. Mucositis: Its occurance, consequences and treatment in the oncology setting. Oncologist. 1998;3:446-51.
Otmani N, Alami R, Hessissen L, Mokhtari A, Soulaymani A, Khattab M. Determinants of severe oral mucositis in paediatric cancer patients: A prospective study. Int J Pediatr Dent. 2011;21:210-16.
Vokurka S, Bystricka E, Koza V, Scudlova J, Pavlicova V, Valentova D, et al. Higher incidence of chemotherapy induced oral mucositis in females: A supplement of multivariate analysis to a randomized multicentre study. Support Care Cancer. 2006;14:974-6.
Figliolia SL, Oliveira DT, Pereira MC, Lauris JR, Mauricio AR, Mello de Andrea ML. Oral mucositis in acute lymphoblastic leukemia: Analysis of 169 pediatric patients. Oral Dis. 2008;14:761-6.
Ahmed KM, Abdulla BK, Saber TK, Salahalddin M. Risk factors of oral mucositis in pediatric) patients (less than 18 years old) receiving chemotherapy. Int J Sci Res.2015;4:245-9.
Yang L, Hu X, Xu L. Impact of methylenetetrahydrofolate reductase (MTHFR) polymorphism on metotheraxte-induced toxicities in acute lymphoblastic leukemia: A meta-analysis. Tumor Biol. 2012;33:1445-54.
Ozdemir N, Celkan T, Baris S, Batar B, Guven M. DNA repair gene XPD and XRCC1 polymorphism and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma. Leuk Res. 2012;36:565-9.
Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, et al. Perspective on cancer therapy induced mucosal injury. Cancer. 2004;100(S9):1995-2025.
European Oncology Nursing Society. Section 4 Oral mucositis guidelines: Guidelines Implementation Toolkit. EONS. 2007 .p. 1-20.
Latosinska JN, Latosinska M. Anticancer drug discovery-from serendipity to rational design. Polandia: INTECH Open Access Publisher; 2013. p. 35-74.
Olif A, Blayer WA, Poplak DG. Methotrexate induced oral mucositis and salivary methotrexate concentration. Cancer Chemother Pharmacol. 1979;2:225-6.
Subramaniam P, Babu KL, Nagarathna J. Oral manifestations in acute lymphoblastic leukemic children under chemotherapy. J Clin Pediatr Dent. 2008;32:319-24.
Sonis ST. A biological approach to mucositis. J Support Oncol. 2004;2:21-32.
Girish Babu KL, Mathew J, Doddamani GM, Narasimhaiah JK, Naik LR. Oral health of children with acute lymphoblastic leukemia: A review. J Orofac Sci. 2016;8:3-11.
Barkokebas A, Silva IG, de Andrade SC, Gueiros LA, Paiva SM, Leao JC. Impact of oral mucositis on oral-health-related quality of life patients diagnosed with cancer. J Oral Pathol Med. 2015;44:746-51.
Elting LS, Cooksley C, Chambers M, Cantor SB, Manzullo E, Rubenstein EB. The burdens of cancer therapy. Cancer. 2004;98:1531-9.
Harris DJ, Eilers J, Harriman A, Cashavelly BJ, Maxwell C. Putting evidence into practice: Evidence based intervention for the management of oral mucositis. Clin J Oncol Nurs. 2008;12(1):141-52.
McGuire DB, Correa ME, Johnson J, Wienandts P. The role of basic oral care and good clinical practice principles in the management of oral mucositis. Support Care Cancer. 2006;14:541-7.
Unduhan
Diterbitkan
Cara Mengutip
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2019 https://creativecommons.org/licenses/by-nc/4.0/
Artikel ini berlisensi Creative Commons Attribution-NonCommercial 4.0 International License.
