Tata Laksana Lambert Eaton Myasthenic Syndrome
DOI:
https://doi.org/10.55175/cdk.v50i11.676Kata Kunci:
Lambert-Eaton myasthenic syndrome, neuromuskular, small cell lung carcinomaAbstrak
Lambert-Eaton myasthenic syndrome (LEMS) merupakan gangguan taut neuromuskular akibat reaksi paraneoplastik atau autoimun. Lebih dari setengah kasus LEMS berhubungan dengan small cell lung carcinoma (SCLC). Manifestasi klinis utama adalah kelemahan otot. Patofisiologi penyakit ini adalah serangan antibodi terhadap voltage-gated calcium channels (VGCCs) saraf terminal presinap, mengakibatkan berkurangnya kadar neurotransmiter asetilkolin (ACh). Berbagai tata laksana seperti tata laksana tumor, immunomodulatory, dan simptomatik telah diteliti, namun diperlukan penelitian lebih lanjut.
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