Anensefali Diduga Akibat Defisiensi Asam Folat
DOI:
https://doi.org/10.55175/cdk.v48i7.96Kata Kunci:
Anensefali, asam folat, defisiensiAbstrak
Anensefali merupakan bagian dari Neural Tube Defect (NTD) yang disebabkan kegagalan penutupan tabung saraf. Salah satu faktor yang paling berpengaruh terhadap anensefali adalah kurangnya asam folat saat masa prekonsepsi dan awal kehamilan. Dilaporkan seorang wanita G3P1A1 umur 25 tahun dengan usia kehamilan 40 minggu, cukup bulan dan janin anensefali. Riwayat persalinan sebelumnya tidak pernah mengalami hal serupa. Selama hamil pasien tidak pernah mengonsumsi asam folat. Pasien melahirkan per vaginam, bayi anensefali meninggal 4 jam setelah dilahirkan. Kondisi pasien stabil dan diperbolehkan pulang.
Anencephaly is part of Neural Tube Deffect (NTD) caused by failure of neural tube closure. One of the most influential factors is folic acid deficiency during preconception and early pregnancy. Case: G3P1A1 woman aged 25 years with 40 weeks of gestation, presented in emergency unit with aterm pregnancy with anencephaly. Previous childbirth history is negative. During pregnancy, patient never consumes folic acid. The baby was vaginally delivered, died 4 hours after birth. Patient was discharged with stable condition.
Unduhan
Referensi
Czeizel AF, Dudas I, Vereczkey A, Banhidy F. Folate deficiency and folic acid supplementation: The prevention of neural-tube defect and congenital heart defects.Nutrients. 2013;5:4760-75.
Saheb HS, Shepur MP, Desai SD, Thomas ST, Haseena S. Anencephaly. J Pharm Sci Res. 2012:4(3):1755-7.
Chandruptala M, Swargam N. Anencephaly: A case report. Int J Sci Stud. 2014;2(7): 255-7
Ekmekci E, Gencdal S. What’s happening when the pregnancies are not terminated in case of anencephaly fetuses. J Clin Res. 2019;11(5):323-6.
Zaganjor I, Sekkarie A, Tsang BL, Williams J, Razzaghi H, Mulinare J, et al. Describing the prevalence of neural tube defect defects worldwide: A systematic literature review. PloS One. 2016;11(4):e0151586.
Mai CT, Isenburg JL, Canfield MA, Meyer RE, Correa A, Alverson CJ, et al. National population-based estimates for major birth defects, 2010-2014. Birth Defects Res. 2019;111(18):1420-35.
Kancherla V. Countries with an immediate potential for primary prevention of spina bifida and anencephaly: Mandatory fortification of wheat flour with folic acid. Birth Defect Res. 2018;110(11):956-65.
Adigun OO, Khetarpal S. Alpha fetoprotein (AFP, maternal serum alpha fetoprotein, MSAFP). StarPearls [Internet]. 2020 [cited 202 June 15]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430750/
Obeidi N, Russell N, Higgins JR, O’Donoghue K. The natural history of anencephaly. Prenat Diagn. 2010;30:357-60.
Greene ND, Copp AJ. Neural tube defects. PMC J. 2014;37:221-42.
Machado IN, Martinez SD, Barini R. Anencephaly: Do the pregnancy and maternal characteristics impact the pregnancy outcome. Internat Scholary Res Network.2012;2012:127490.
Hall JW, Denne N, Williams D, Balcik BJ. Check the head: Emergency ultrasound diagnosis of fetal anencephaly. Western J Emerg Med. 2014;27(4):460-4.
ACOG Practice Bull. Neural tube defects. Obstet Gynecol. 2017;130(6):279–90.
Crider KS, Devine O, Hao L, Dowling NF, Li S, Molloy AM, et al. Population red blood cell folate concentrations for prevention of neural tube defects: Bayesian model. BMJ 2014;349:4554.
World Heath Organization. Guideline: Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects.Geneva: WHO; 2015.
Arya SS, Pavitra K. Folate: Source, production and bioavailability. Peer-reviewed Article. 2012;23(4):23-27.
World Health Organization. Periconceptional folic acid supplementation to prevent neural tube defects [Internet]. 2019 [cited 2020 June 16]. Available from: https://www.who.int/elena/titles/folate_periconceptional/en/
Center for Disease Control and Prevention. Folic acid & neural tube defects: Data & statistics [Internet]. 2017 [cited 2020 June 16]. Available from: https://www.cdc.gov/ncbddd/birthdefectscount/data.html
Unduhan
Diterbitkan
Cara Mengutip
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2021 Cermin Dunia Kedokteran
Artikel ini berlisensi Creative Commons Attribution-NonCommercial 4.0 International License.
