Penggunaan Parasetamol pada COVID-19
DOI:
https://doi.org/10.55175/cdk.v48i7.98Kata Kunci:
COVID-19, parasetamol, glutationAbstrak
Latar belakang: Parasetamol sering digunakan untuk mengobati gejala demam pada COVID-19. Banyak hipotesis yang menyebutkan hubungan kadar Glutathione (GSH) dengan derajat keparahan COVID-19, sedangkan parasetamol dapat menurunkan kadar GSH. Hingga saat ini, belum ada panduan khusus untuk dosis penggunaan obat parasetamol pada pasien COVID-19.
Background: Paracetamol is often used to treat fever symptoms in COVID-19. Many hypotheses state the relationship between Glutathione (GSH) levels and the severity of COVID-19, while paracetamol can reduce GSH levels. To date, there are no specific guidelines for the dosage of paracetamol in patients with COVID-19
Unduhan
Referensi
Inciardi R, Lupi L, Zaccone G, Italia L, Raffo M, Tomasoni D, et al. Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19). JAMA Cardiol.2020;5(7):819.doi: 10.1001/jamacardio.2020.1096
Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterization and epidemiology of 2019 novel coronavirus:implications for virus origins and receptor binding. Lancet. 2020;395(10224):565-74. doi: 10.1016/S0140-6736(20)30251-8
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5
Sestili P, Fimognari C. Parasetamol-induced glutathione consumption: Is there a link with severe COVID-19 illness? Frontiers in Pharmacology. 2020;11.doi: 10.3389/fphar.2020.579944
KEMENKES RI. Pedoman pencegahan dan pengendalian coronavirus disease (COVID19). Germas; 2020
Yuki K, Fujiogi M, Koutsogiannaki S. COVID-19 pathophysiology: A review. Clin Immunol. 2020;215:108427.doi: 10.1016/j.clin.2020.108427
Bergmann C, Silverman R. COVID-19: Coronavirus replication, pathogenesis, and therapeutic strategies. Cleveland Clin J Med. 2020;87(6):321-7.doi: 10.3949/ccjm.87a.20047
Silvagno F, Vernone A, Pescarmona G. The role of glutathione in protecting against the severe inflammatory response triggered by COVID-19. Antioxidants.2020;9(7):624.doi: doi:10.3390/antiox9070624
Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury. Nature Med. 2005;11(8):875-9.doi: 10.1038/nm1267
Basi Z, Turkoglu V. In vitro effect of oxidized and reduced glutathione peptides on angiotensin converting enzyme purified from human plasma. J Chromatogr B.2019;1104:190-5.doi : 10.1016/j.jchromb.2018.11.023
Vajapey R, Rini D, Walston J, Abadir P. The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance. Frontiers in Physiology. 2014;5:439.
PDPI. Pedoman tatalaksana COVID-19. 3rd Ed. 2020 Dec.
Moyer A, Fridley B, Jenkins G, Batzler A, Pelleymounter L, Kalari K, et al. Acetaminophen-NAPQI hepatotoxicity: A cell line model system genome-wide association study. Toxicol Sci. 2010;120(1):33-41. doi: 10.1093/toxsci/kfq375
Dimova S, Hoet P, Dinsdale D, Nemery B. Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and type II pneumocytes in vitro. Internat J Biochemistr Cell Biol. 2005;37(8):1727-37. doi: 10.1016/j.biocel.2005.03.005
Unduhan
Diterbitkan
Cara Mengutip
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2021 Cermin Dunia Kedokteran
Artikel ini berlisensi Creative Commons Attribution-NonCommercial 4.0 International License.
