The Effect of Amino Acid Administration in Preventing Acute Kidney Injury (AKI) Following Cardiac Surgery
Systematic Review
DOI:
https://doi.org/10.55175/cdk.v52i11.1724Keywords:
Acute kidney injury, amino acid, cardiac surgeryAbstract
Introduction: The administration of amino acids can be a safe and effective approach to reducing the risk of acute kidney injury (AKI) following cardiac surgery. Methods: In this systematic review, data were obtained from scientific databases PubMed, ProQuest, ScienceDirect, and Google Scholar, covering publications from January 1 to November 1, 2024. This systematic review analyzed 3 randomized controlled trials involving a total of 3,647 patients. Results: AKI was observed in 26.6% patients in the amino acid group compared to 31.9% in the control group (RR = 0.67; 95% CI [0.43–1.06]; I² = 52.5%; p = 0.0854). Additionally, the risk of stage 1 AKI (21.1% vs 24.5%; RR 0.86; 95% CI [0.77–0.96]; I² = 0%) and stage 3 AKI (0.15% vs 0.3%; RR 0.52; 95% CI [0.34–0.81]; I² = 0%) was significantly lower in the amino acid group. No serious adverse events were reported in the included studies. Risk of bias was assessed using the Cochrane Risk of Bias-2 (RoB2) tool, and data analysis was performed using R software. Conclusion: Findings suggest that amino acids offer clinical benefits in AKI prevention, particularly in stages 1 and 3, without increasing the risk of severe adverse effects
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Copyright (c) 2025 Lukman Nur Rahman, Munzir Makarim, Muh. Azrief Khaidir Anjar, Muh. Syawaludin Sakti Maulana, Rais Trisiyambudin, Greyson Efraldi Sampe, Rifal Faali, Muhammad Hilmi Falah, Muh. Ikmaluddin Furqon, Dzar Ghifari Muh Rizal
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