Respons Sistem Imun pada Epilepsi
DOI:
https://doi.org/10.55175/cdk.v45i11.692Keywords:
Epilepsi, sistem imunAbstract
Epilepsi merupakan kondisi kronis dengan penyebab multifaktorial. Jumlah pasien resisten obat sekitar 20-40% diduga akibat keterlibatan peran imun dalam epileptogenesis. Beberapa komponen imunitas neuron berperan pada patogenesis epilepsi dan penggunaan obat anti epilepsi berpengaruh pada sistem imun. Obat anti epilepsi bersifat imunosupresan; imunitas innate dan adaptif berubah bermakna saat dan setelah kejang.
Epilepsy is a chronic condition with multifactorial causes. Aproximately 20-40% patients are drug resistant thought to be due to role of immunity in epileptogenesis. Some components of immunity in neurons play a role in the pathogenesis of epilepsy. Anti-epilepsy drugs are immunosuppressive; innate; adaptive immunity changes significantly during and after seizures.
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