Sarkopenia pada Pasien Sirosis Hepatis
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DOI:
https://doi.org/10.55175/cdk.v52i3.1253Kata Kunci:
Penyakit hati kronis, sarkopenia, sirosis hepatisAbstrak
Sarkopenia merupakan kondisi yang ditandai dengan penurunan massa, kekuatan, dan fungsi otot. Sirosis hepatis yang merupakan kondisi katabolik dengan pemecahan protein otot melebihi sintesisnya, erat hubungannya dengan terjadinya sarkopenia. Asosiasi ini terkait dengan komplikasi sirosis yang lebih parah, kunjungan ke rumah sakit yang lebih sering, dan kematian dini. Tinjauan pustaka ini diharapkan dapat memberikan wawasan pentingnya pencegahan, pengawasan, dan manajemen sirosis hepatis yang tepat.
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Referensi
Ardeljan AD, Hurezeanu R. Sarcopenia. StatPearls [Internet]. 2023. Available from: http://www.ncbi.nlm.nih.gov/books/NBK560813/.
Dhaliwal A, Armstrong MJ. Sarcopenia in cirrhosis: A practical overview. Clin Med (Lond). 2020;20(5):489–92. DOI: 10.7861/clinmed.2020-0089.
Topan MM, Sporea I, Danila M, Popescu A, Ghiuchici AM, Lupuşoru R, et al. Impact of sarcopenia on survival and clinical outcomes in patients with liver cirrhosis. Frontiers in Nutrition 2021;8:1–6. DOI: 10.3389/fnut.2021.766451.
Sharma B, John S. Hepatic cirrhosis. StatPearls [Internet]. 2023. Available from: http://www.ncbi.nlm.nih.gov/books/NBK482419/.
Liu YB, Chen MK. Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions. World J Gastroenterol. 2022;28(41):5910–30. DOI: 10.3748/wjg.v28.i41.5910.
Huang DQ, Terrault NA, Tacke F, Gluud LL, Arrese M, Bugianesi E, et al. Global epidemiology of cirrhosis — Aetiology, trends and predictions. Nat Rev Gastroenterol Hepatol. 2023;20(6):388–98. DOI: 10.1038/s41575-023-00759-2.
Tchelepi H, Ralls PW, Radin R, Grant E. Sonography of diffuse liver disease. J Ultrasound Med. 2002;21(9):1023–32; quiz 1033–4. DOI: 10.7863/jum.2002.21.9.1023.
Burrel M, Llovet JM, Ayuso C, Iglesias C, Sala M, Miquel R, et al. MRI angiography is superior to helical CT for detection of HCC prior to liver transplantation: An explant correlation. Hepatology. 2003;38(4):1034–42. DOI: 10.1053/jhep.2003.50409.
Regev A, Berho M, Jeffers LJ, Milikowski C, Molina EG, Pyrsopoulos NT, et al. Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol. 2002;97(10):2614–8. DOI: 10.1111/j.1572-0241.2002.06038.x.
Santilli V, Bernetti A, Mangone M, Paoloni M. Clinical definition of sarcopenia. Clin Cases Miner Bone Metab. 2014;11(3):177–80. PMID: 25568649.
Ogawa S, Yakabe M, Akishita M. Age-related sarcopenia and its pathophysiological bases. Inflammation and Regeneration. 2016;36(1):17. DOI: 10.1186/s41232-016-0022-5.
Beaudart C, McCloskey E, Bruyere O, Cesari M, Rolland Y, Rizzoli R, et al. Sarcopenia in daily practice: Assessment and management. BMC Geriatr. 2016;16(1):170. DOI: 10.1186/s12877-016-0349-4.
Kim TN, Choi KM. Sarcopenia: Definition, epidemiology, and pathophysiology. J Bone Metab. 2013;20(1):1–10. DOI: 10.11005/jbm.2013.20.1.1.
Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, et al. Sarcopenia: Revised European consensus on definition and diagnosis. Age Ageing 2019;48(1):16–31. DOI: 10.1093/ageing/afy169.
Nishikawa H, Shiraki M, Hiramatsu A, Moriya K, Hino K, Nishiguchi S. Japan society of hepatology guidelines for sarcopenia in liver disease (1st edition): Recommendation from the working group for creation of sarcopenia assessment criteria. Hepatol Res. 2016;46(10):951–63. DOI: 10.1111/hepr.12774.
Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, et al. Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc. 2020;21(3):300-307.e2. DOI: 10.1016/j.jamda.2019.12.012.
Dasarathy S, Merli M. Sarcopenia from mechanism to diagnosis and treatment in liver disease. J Hepatol. 2016;65(6):1232–44. DOI: 10.1016/j.jhep.2016.07.040.
Dasarathy S. Cause and management of muscle wasting in chronic liver disease. Curr Opin Gastroenterol. 2016;32(3):159–65. DOI: 10.1097/MOG.0000000000000261.
Holecek M, Kandar R, Sispera L, Kovarik M. Acute hyperammonemia activates branched-chain amino acid catabolism and decreases their extracellular concentrations: different sensitivity of red and white muscle. Amino Acids 2011;40(2):575–84. DOI: 10.1007/s00726-010-0679-z.
Davuluri G, Allawy A, Thapaliya S, Rennison JH, Singh D, Kumar A, et al. Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress. J Physiol. 2016;594(24):7341–60. DOI: 10.1113/JP272796.
Qiu J, Thapaliya S, Runkana A, Yang Y, Tsien C, Mohan ML, et al. Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF-κB-mediated mechanism. Proc Natl Acad Sci U S A. 2013;110(45):18162–7. DOI: 10.1073/pnas.1317049110.
Ebadi M, Bhanji RA, Mazurak VC, Montano-Loza AJ. Sarcopenia in cirrhosis: From pathogenesis to interventions. J Gastroenterol. 2019;54(10):845–59. DOI: 10.1007/s00535-019-01605-6.
Bhanji RA, Narayanan P, Allen AM, Malhi H, Watt KD. Sarcopenia in hiding: The risk and consequence of underestimating muscle dysfunction in nonalcoholic steatohepatitis. Hepatology 2017;66(6):2055–65. DOI: 10.1002/hep.29420.
Calmet F, Martin P, Pearlman M. Nutrition in patients with cirrhosis. Gastroenterol Hepatol (NY). 2019;15(5):248–54. PMID: 31360138.
Johnson TM, Overgard EB, Cohen AE, DiBaise JK. Nutrition assessment and management in advanced liver disease. Nutr Clin Pract. 2013;28(1):15–29. DOI: 10.1177/0884533612469027.
Plauth M, Merli M, Kondrup J, Weimann A, Ferenci P, Muller MJ, et al. ESPEN guidelines for nutrition in liver disease and transplantation. Clin Nutr. 1997;16(2):43–55. DOI: 10.1016/s0261-5614(97)80022-2.
Eghtesad S, Poustchi H, Malekzadeh R. Malnutrition in liver cirrhosis: The influence of protein and sodium. Middle East J Dig Dis. 2013;5(2):65–75. PMID: 24829672.
Allen SL, Quinlan JI, Dhaliwal A, Armstrong MJ, Elsharkawy AM, Greig CA, et al. Sarcopenia in chronic liver disease: Mechanisms and countermeasures. Am J Physiol-Gastrointestinal Liver Physiol. 2021;320(3):G241–57. DOI: 10.1152/ajpgi.00373.2020.
Hurst C, Robinson SM, Witham MD, Dodds RM, Granic A, Buckland C, et al. Resistance exercise as a treatment for sarcopenia: Prescription and delivery. Age Ageing 2022;51(2):afac003. DOI: 10.1093/ageing/afac003.
Dent E, Morley JE, Cruz-Jentoft AJ, Arai H, Kritchevsky SB, Guralnik J, et al. International clinical practice guidelines for sarcopenia (ICFSR): Screening, diagnosis and management. J Nutr Health Aging. 2018;22(10):1148–61. DOI: 10.1007/s12603-018-1139-9.
Manini T, Marko M, VanArnam T, Cook S, Fernhall B, Burke J, et al. Efficacy of resistance and task-specific exercise in older adults who modify tasks of everyday life. J Gerontol A Biol Sci Med Sci. 2007;62(6):616–23. DOI: 10.1093/gerona/62.6.616.
Sinclair M, Grossmann M, Gow PJ, Angus PW. Testosterone in men with advanced liver disease: abnormalities and implications. J Gastroenterol Hepatol. 2015;30(2):244–51. DOI: 10.1111/jgh.12695.
Kim Y. Emerging treatment options for sarcopenia in chronic liver disease. Life (Basel). 2021;11(3):250. DOI: 10.3390/life11030250.
Butterworth RF. L-ornithine L-aspartate for the treatment of sarcopenia in chronic liver disease: The taming of a vicious cycle. Can J Gastroenterol Hepatol. 2019;2019:8182195. DOI: 10.1155/2019/8182195.
Lockwood AH. Blood ammonia levels and hepatic encephalopathy. Metab Brain Dis. 2004;19(3–4):345–9. DOI: 10.1023/b:mebr.0000043980.74574.eb.
Hiramatsu A, Aikata H, Uchikawa S, Ohya K, Kodama K, Nishida Y, et al. Levocarnitine use is associated with improvement in sarcopenia in patients with liver cirrhosis. Hepatol Commun. 2019;3(3):348–55. DOI: 10.1002/hep4.1309.
Nishikawa H, Asai A, Fukunishi S. The significance of zinc in patients with chronic liver disease. Nutrients 2022;14(22):4855. DOI: 10.3390/nu14224855.
Dzik KP, Kaczor JJ. Mechanisms of vitamin D on skeletal muscle function: Oxidative stress, energy metabolism and anabolic state. Eur J Appl Physiol. 2019;119(4):825–39. DOI: 10.1007/s00421-019-04104-x.
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