N-butylphthalide: Neuroprotektor untuk Stroke Iskemik
DOI:
https://doi.org/10.55175/cdk.v52i1.1290Kata Kunci:
NBP, N-butylphthalide, neuroprotector, ischemic strokeAbstrak
Stroke, terutama stroke iskemik, masih merupakan salah satu masalah kesehatan yang menjadi prioritas di Indonesia dengan beban dan biaya yang besar. Terapi utama stroke iskemik, yaitu reperfusi dengan terapi trombolitik atau trombektomi, memiliki berbagai tantangan terutama rentang waktu yang direkomendasikan karena keterbatasan fasilitas dan infrastruktur. N-butylphthalide (NBP) merupakan neuroprotektor yang memiliki potensi memperbaiki mikrosirkulasi serebral, melindungi sawar darah otak, melindungi sel neuron dari apoptosis, merangsang neurogenesis, serta menjaga survivabilitas sel neuron dalam kondisi stroke iskemik berdasarkan studi pre-klinik. Secara klinik, NBP menunjukkan manfaat terutama berupa perbaikan disabilitas pasca-stroke. NBP merupakan neuroprotektor yang menjanjikan untuk luaran klinik stroke iskemik yang lebih baik.
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Referensi
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