Hasil Luaran Janin pada Kehamilan yang Terinfeksi Sifilis yang Diobati dengan Penicillin G: Tinjauan Sistematis
Analisis
DOI:
https://doi.org/10.55175/cdk.v52i1.1297Kata Kunci:
Kongenital sifilis, penicillin G, infeksi sifilis pada kehamilan, tata laksana sifilisAbstrak
Latar belakang: Infeksi sifilis pada kehamilan dapat menyebabkan sifilis kongenital. Terapi penicillin bertujuan untuk mengatasi infeksi sifilis pada ibu hamil, agar janin tidak tertular dan tidak terjadi sifilis kongenital. Dilakukan tinjauan literatur sistematis untuk mengetahui khasiat penicillin G dengan meninjau parameter hasil. Metode: Tinjauan literatur sistematis mengikuti pedoman preferred reporting items for systematic reviews
and meta-analysis (PRISMA). Hasil: Melalui pencarian data di PubMed, Science Direct, dan Cochrane menggunakan kata kunci ‘Antibiotik’ ‘Hamil’ ‘Kehamilan’ ‘Sifilis’ dan ‘Tata laksana’, didapatkan 230 artikel. Saat seleksi, terdapat 25 artikel duplikat, 135 artikel tidak memenuhi kriteria inklusi, tinjauan literatur 75 artikel, populasi bukan wanita hamil 58 artikel, sehingga didapatkan 6 jurnal yang memenuhi kriteria iklusi. Simpulan: Penicillin G benzathine adalah antibiotik yang paling umum digunakan untuk mengobati sifilis pada kehamilan. Sebanyak 1.190 kasus (26,26%) sifilis kongenital ditemukan di antara 4.531 wanita hamil yang terinfeksi sifilis dan menerima terapi penicillin G benzathine. Insiden sifilis kongenital didapatkan 2,4% pada ibu hamil yang mendapat terapi sejak trimester pertama. Kejadian sifilis kongenital meningkat 12 kali jika terapi diberikan pada trimester kedua dan 33 kali jika diberikan pada trimester ketiga.
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Referensi
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