Pendekatan Diagnosis Ensefalomielitis Diseminata Akut
Tinjauan Pustaka
DOI:
https://doi.org/10.55175/cdk.v52i2.1311Kata Kunci:
EMDA, ensefalomielitis diseminata akut, penyakit demielinisasiAbstrak
Ensefalomielitis diseminata akut (EMDA) merupakan kelainan neurologis akut dengan karakteristik demielinisasi sistem saraf pusat (SSP). Penyakit ini dapat menyerang seluruh kelompok usia, dan lebih banyak pada anak laki-laki dengan riwayat paparan infeksi virus, bakteri, ataupun vaksinasi. Perjalanan penyakit EMDA umumnya akut dan monofasik dengan temuan defisit neurologis polifokal. EMDA tidak memiliki gejala spesifik karena manifestasi klinis ditentukan oleh lokasi demielinisasi. Pemeriksaan spesifik untuk EMDA tidak tersedia, sehingga diagnosis ditegakkan berdasarkan eksklusi.
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Esposito S, Di Pietro GM, Madini B, Mastrolia MV, Rigante D. A spectrum of inflammation and demyelination in acute disseminated encephalomyelitis (ADEM) of children. Autoimmun Rev. 2015;14(10):923–9. DOI: 10.1016/j.autrev.2015.06.002.
Gelibter S, Bellavia G, Arbasino C, Arno N, Glorioso M, Mazza S, et al. Encephalopathy as a prognostic factor in adults with acute disseminated encephalomyelitis following COVID-19. J Neurol. 2022;269(5):2293–300. DOI: 10.1007/s00415-021-10947-2.
Anilkumar AC, Foris LA, Tadi P. Acute disseminated encephalomyelitis. StatPearls [Internet]. 2023 [cited 2023 Aug 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430934/.
Wang CX. Assessment and management of acute disseminated encephalomyelitis (ADEM) in the pediatric patient. Paediatr Drugs. 2021;23(3):213–21. DOI: 10.1007/s40272-021-00441-7.
Cautilli F, Feleppa M, Valeriani M, Papetti L, Monte G, Midulla F, et al. A case of acute disseminated encephalomyelitis after SARS-CoV-2 infection in pediatric patients. Front Neurol. 2023;14:1099458. DOI: 10.3389/fneur.2023.1099458.
Mousa H, Patel TH, Meadows I, Ozdemir B. Acute disseminated encephalomyelitis (ADEM) after consecutive exposures to Mycoplasma and COVID vaccine: A case report. Cureus. 2022;14(6):e26258. DOI: 10.7759/cureus.26258.
Javed A, Khan O. Acute disseminated encephalomyelitis. Handb Clin Neurol. 2014;123:705-17. DOI: 10.1016/B978-0-444-53488-0.00035-3.
Paolilo RB, Deiva K, Neuteboom R, Rostasy K, Lim M. Acute disseminated encephalomyelitis: Current perspectives. Children (Basel). 2020;7(11):210. DOI: 10.3390/children7110210.
Hatharasinghe A, Akhondi H, Pepito D. Acute disseminated encephalomyelitis. HCA Healthcare J Med. 2020;1(2):77-82. DOI: 10.36518/2689-0216.1038.
Massa S, Fracchiolla A, Neglia C, Argentiero A, Esposito S. Update on acute disseminated encephalomyelitis in children and adolescents. Children (Basel). 2021;8(4):280. DOI: 10.3390/children8040280.
Alicino C, Infante MT, Gandoglia I, Miolo N, Mancardi GL, Zappettini S, et al. Acute disseminated encephalomyelitis with severe neurological outcomes following virosomal seasonal influenza vaccine. Hum Vaccin Immunother. 2014;10(7):1969–73. DOI: 10.4161/hv.28961.
AlZeera AJ, Alkhaja A, Noor DH, Alsaffar SMR. Adult-onset acute disseminated encephalomyelitis refractory to steroids. Cureus 2021;13(10):e18669. DOI: 10.7759/cureus.18669.
Li K, Li M, Wen L, Wang Q, Ding X, Wang J. Clinical presentation and outcomes of acute disseminated encephalomyelitis in adults worldwide: Systematic review and meta-analysis. Front Immunol. 2022;13:870867. DOI: 10.3389/fimmu.2022.870867.
Ayed H, Chaudhary MW, AlBaradie R, Mir A. Use of cyclophosphamide in a child with fulminant acute disseminated encephalomyelitis. Child Neurol Open. 2018;5:2329048X18754631. DOI: 10.1177/2329048X18754631.
Rothenberg J, Lastra A, Alvarez G, Irwin R. Acute disseminated encephalomyelitis responsive to cyclophosphamide therapy: A case report. J Med Cases. 2015;6(7):290–4. DOI: 10.14740/jmc2176w.
Pierro A, Posa A, Addona T, Petrosino A, Galasso V, Tanzilli A, et al. Magnetic resonance imaging of autoimmune demyelinating diseases as a diagnostic challenge for radiologists: Report of two cases and literature review. Life (Basel). 2022;12(4):488. DOI: 10.3390/life12040488.
Etemadifar M, Neshatfar A, Nikanpour Y, Salari M. The characteristics of acute disseminated encephalomyelitis can slightly vary based on the geographical region. J Neurol Neurophysiol. 2019;10(2):486. DOI: 10.4172/2155-9562.1000486.
Salama S, Khan M, Pardo S, Izbudak I, Levy M. MOG antibody–associated encephalomyelitis/encephalitis. Mult Scler. 2019;25(11):1427–33. DOI: 10.1177/1352458519837705.
Hacohen Y, Banwell B. Treatment approaches for mog-ab-associated demyelination in children. Curr Treat Options Neurol. 2019;21(1):2. DOI: 10.1007/s11940-019-0541-x.
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