Peran Antitrombin III sebagai Penanda Sepsis pada Anak
DOI:
https://doi.org/10.55175/cdk.v50i11.914Kata Kunci:
Anak, antitrombin III, sepsisAbstrak
Sepsis adalah disfungsi organ yang mengancam kehidupan yang disebabkan oleh disregulasi imun terhadap infeksi. Antitrombin III merupakan glikoprotein terikat plasma yang tunggal dan termasuk golongan penghambat serin protease (serpin); produksinya di hati menurun pada keadaan sepsis.
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Latief A, Antonius HP, Dadang HS, Enny HA, G Dharma M, et al. Diagnosis dan tatalaksana sepsis pada anak. Unit Kerja Koordinasi Pediatri Gawat Darurat Ikatan Dokter Anak Indonesia. Ikatan Dokter Anak Indonesia; 2010 .p. 1-18
Goldstein B, Giroir B, Randolph A. International Pediatric Sepsis Consensus Conference: Definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6(1):2-4.
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012. Pediatr Crit Care Med. 2013;41(2):580-637.
Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use off innovative therapies in sepsis. CHEST. 1992;101:1644-55.
Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6(1):2-4.
Melendez E, Bachur R. Advances in emergency management of pediatric sepsis. Curr Opin Pediatrics. 2006;18:245-53.
Priyatiningsih DR, Latief A, Pudjiadi AH. Karakteristik sepsis di pediatric intensive care unit RSUPN dr. Cipto Mangunkusumo. Jakarta: Fakultas Kedokteran Universitas Indonesia; 2016
Deutschman CS, Tracey KJ. Sepsis: Current dogma and new perspectives. Immunity 2014;40:463-75.
Jui J. Septic shock. In: Judith E. Tintinalli, Stapczynski JS, Ma OJ, Cline DM, editors. Tintinalli’s emergency meicine: A comprehensive study guide. New York: McGraw-Hill; 2011 .p. 1003-14
Opal SM. Concept of PIRO as a new conceptual framework to understand sepsis. Pediatr Crit Care Med. 2005;6:55-60.
Weiss SL, Fitzgerald JC, Maffei FA, Kane JM, Rodriguez-Nunez A, Hsing DD, et al. Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study. Crit Care 2015;19:325-34.
Cardoso T, Teixeira-Pinto A, Rodrigues PP, Aragao I, Costa-Pereira A, Sarmento AE. Predisposition, insult/infection, response and organ dysfunction (PIRO): A pilot clinical staging system for hospital mortality in patients with infection. PLoS One 2013;8:e70806.
Chan T, Gu F. Early diagnosis of sepsis using serum biomarkers. Expert Rev Mol Diagn. 2011;11:487-96.
Sepanski RJ, Godambe SA, Mangum CD, Bovat CS, Zaritsky AL, Shah SH. Designing a pediatric severe sepsis screening tool. Front Pediatr. 2014;2:56.
Afshari A, Wetterslev J, Brok J, Moller A. Antithrombin III in critically ill patients: Systematic review with meta-analysis and trial sequential analysis. BMJ. 2007;335:1248-51
Wiedermann CJ, Hoffmann JN, Juers M, Ostermann H, Kienast J, Briegel J. High dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: Efficacy and safety. Crit Care Med. 2006;34:285-92
Rodgers GM. Role of antithrombin concentrate in treatment of hereditary antithrombin deficiency. An update. Thromb Haemost. 2009;101(5):806–12.
Ersoy B, Nehir H, Altinoz S, Yilmaz O, Dundar PE, Aydogan A. Prognostic value of initial antithrombin levels in neonatal sepsis. Indian Pediatr. 2007;44:581-4
Maclean PS, Tait RC. Hereditary and acquired antithrombin deficiency. Drugs 2007;67(10):1429–40.
Beshlawy AE, Alaraby I, Hussein HA, Abou-Elew HH, Kader MSEMA. Study of protein C, protein S, and antithrombin III in newborns with sepsis. Pediatr Crit Care Med. 2010;11(1):52–9.
Muntaha ST, Akram W, Hassan F. Prognostic value of anti-thrombin III level in neonatal sepsis. J Rawalpindi Medical College (JRMC). 2016;20(3):202-5
Iba T, Saitoh D. Efficacy of antithrombin in preclinical and clinical applications for sepsis-associated disseminated intravascular coagulation. J Intensive Care 2014;2(1):66.
Choi Q, Hong KH, Kim JE, Kim HK. Changes in plasma levels of natural anticoagulants in disseminated intravascular coagulation: High prognostic value of antithrombin and protein C in patients with underlying sepsis or severe infection. Ann Lab Med. 2014;34:85-91. https://doi.org/10.3343/alm.2014.34.2.85
Faix JD. Biomarkers of sepsis. Crit Rev Clin Lab Sci. 2013;50(1):23-6.
Lobo SM, Lobo FRM. Markers and mediators of inflammatory response in infection and sepsis. RBTI. 2007;19(2):211-15.
Hagag AA, Elmahdy HS, Ezzat AA. Prognostic value of plasma pro-adrenomedullin and antithrombin levels in neonatal sepsis. Indian Pediatr. 2011;48:471-3.
Lauterbach R, Pawlik D, Radziszewska R, Wozniak J, Rytlewski K. Plasma antithrombin III and protein C levels in early recognition of late-onset sepsis in newborns. Eur J Pediatr. 2006;165:585-9.
Wiedermann CJ. Clinical review: Molecular mechanisms underlying the role of antithrombin in sepsis. Crit Care 2006;10(209):1-9.
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